Neurobiological mechanisms associated with facial affect recognition deficits after traumatic brain injury

Autor: Brenna C. McDonald, Yang Wang, Michelle A. Keiski, John D. West, Dawn Neumann
Rok vydání: 2015
Předmět:
Adult
Male
medicine.medical_specialty
Traumatic brain injury
Cognitive Neuroscience
Emotions
Poison control
Audiology
Neuropsychological Tests
Facial recognition system
050105 experimental psychology
Developmental psychology
03 medical and health sciences
Behavioral Neuroscience
Cellular and Molecular Neuroscience
0302 clinical medicine
Neuroimaging
Injury prevention
Brain Injuries
Traumatic
medicine
Humans
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
Neuroradiology
medicine.diagnostic_test
05 social sciences
Neuropsychology
Recognition
Psychology
Middle Aged
medicine.disease
Magnetic Resonance Imaging
nervous system diseases
Facial Expression
Psychiatry and Mental health
Affect
nervous system
Neurology
Face
Female
Neurology (clinical)
Functional magnetic resonance imaging
Psychology
Facial Recognition
030217 neurology & neurosurgery
Zdroj: Brain imaging and behavior. 10(2)
ISSN: 1931-7565
Popis: The neurobiological mechanisms that underlie facial affect recognition deficits after traumatic brain injury (TBI) have not yet been identified. Using functional magnetic resonance imaging (fMRI), study aims were to 1) determine if there are differences in brain activation during facial affect processing in people with TBI who have facial affect recognition impairments (TBI-I) relative to people with TBI and healthy controls who do not have facial affect recognition impairments (TBI-N and HC, respectively); and 2) identify relationships between neural activity and facial affect recognition performance. A facial affect recognition screening task performed outside the scanner was used to determine group classification; TBI patients who performed greater than one standard deviation below normal performance scores were classified as TBI-I, while TBI patients with normal scores were classified as TBI-N. An fMRI facial recognition paradigm was then performed within the 3T environment. Results from 35 participants are reported (TBI-I = 11, TBI-N = 12, and HC = 12). For the fMRI task, TBI-I and TBI-N groups scored significantly lower than the HC group. Blood oxygenation level-dependent (BOLD) signals for facial affect recognition compared to a baseline condition of viewing a scrambled face, revealed lower neural activation in the right fusiform gyrus (FG) in the TBI-I group than the HC group. Right fusiform gyrus activity correlated with accuracy on the facial affect recognition tasks (both within and outside the scanner). Decreased FG activity suggests facial affect recognition deficits after TBI may be the result of impaired holistic face processing. Future directions and clinical implications are discussed.
Databáze: OpenAIRE
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