Deregulation of TLR4 signaling pathway characterizes Bicuspid Aortic valve syndrome
| Autor: | Calogera Pisano, Alessandra Iaccarino, Michele Madonna, Carmela Rita Balistreri, Mariangela Peruzzi, Valeriana Cesarini, Giacomo Frati, Elena Cavarretta, Alberto Allegra, Michele Torella, Sebastiano Sciarretta, Antonino G.M. Marullo, Giovanni Ruvolo, Sonia Schiavon, Ernesto Greco |
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| Přispěvatelé: | Balistreri, Carmela R, Marullo, Antonino G M, Madonna, Michele, Cavarretta, Elena, Allegra, Alberto, Cesarini, Valeriana, Iaccarino, Alessandra, Schiavon, Sonia, Peruzzi, Mariangela, Greco, Ernesto, Sciarretta, Sebastiano, Pisano, Calogera, Ruvolo, Giovanni, Torella, Michele, Frati, Giacomo |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Aortic valve Bicuspid Aortic valve syndrome Heart Valve Diseases lcsh:Medicine Disease 0302 clinical medicine Bicuspid aortic valve Bicuspid Aortic Valve Disease TLR4 lcsh:Science Aorta Aged 80 and over Multidisciplinary Syndrome Middle Aged Pathophysiology medicine.anatomical_structure Aortic Valve cardiovascular system Cardiology Female Signal Transduction medicine.medical_specialty Article Proinflammatory cytokine 03 medical and health sciences medicine.artery Internal medicine Ascending aorta medicine Humans bicuspid valve Aged aortic disease BAV TLR4 AAA Tumor Necrosis Factor-alpha business.industry Interleukins lcsh:R Settore MED/23 - Chirurgia Cardiaca Valvular disease medicine.disease Toll-Like Receptor 4 030104 developmental biology lcsh:Q business Complication 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019) Scientific reports (Nature Publishing Group) 9 (2019). doi:10.1038/s41598-019-47412-0 info:cnr-pdr/source/autori:Balistreri, Carmela R.; Marullo, Antonino G. M.; Madonna, Michele; Cavarretta, Elena; Allegra, Alberto; Cesarini, Valeriana; Iaccarino, Alessandra; Schiavon, Sonia; Peruzzi, Mariangela; Greco, Ernesto; Sciarretta, Sebastiano; Pisano, Calogera; Ruvolo, Giovanni; Torella, Michele; Frati, Giacomo/titolo:Deregulation of TLR4 signaling pathway characterizes Bicuspid Aortic valve syndrome/doi:10.1038%2Fs41598-019-47412-0/rivista:Scientific reports (Nature Publishing Group)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:9 Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-47412-0 |
| Popis: | Bicuspid aortic valve (BAV) disease is recognized to be a syndrome with a complex and multifaceted pathophysiology. Its progression is modulated by diverse evolutionary conserved pathways, such as Notch-1 pathway. Emerging evidence is also highlighting the key role of TLR4 signaling pathway in the aortic valve pathologies and their related complications, such as sporadic ascending aorta aneurysms (AAA). Consistent with these observations, we aimed to evaluate the role of TLR4 pathway in both BAV disease and its common complication, such as AAA. To this aim, 70 subjects with BAV (M/F 50/20; mean age: 58.8 ± 14.8 years) and 70 subjects with tricuspid aortic valve (TAV) (M/F 35/35; mean age: 69.1 ± 12.8 years), with and without AAA were enrolled. Plasma assessment, tissue and gene expression evaluations were performed. Consistent with data obtained in the previous study on immune clonotypic T and B altered responses, we found reduced levels of systemic TNF-α, IL-1, IL-6, IL-17 cytokines in BAV cases, either in the presence or absence of AAA, than TAV cases (p |
| Databáze: | OpenAIRE |
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