Laboratory animal allergy is preventable in modern research facilities

Autor: SJ Schofield, Bernadette Fitzgerald, Johanna Feary, James Potts, Paul Cullinan, Meinir Jones, Jennifer Canizales
Přispěvatelé: The Colt Foundation
Rok vydání: 2019
Předmět:
Male
Respiratory System
DETERMINANTS
PHENOTYPE
Immunoglobulin E
medicine.disease_cause
Atopy
Mice
0302 clinical medicine
Allergen
Allergic symptoms
Medicine
030212 general & internal medicine
Animal Husbandry
OCCUPATIONAL ASTHMA
11 Medical and Health Sciences
biology
WORKERS
Middle Aged
Housing
Animal
SENSITIZATION
ATOPY
Air Pollution
Indoor
cardiovascular system
Female
SMOKING
Safety
Life Sciences & Biomedicine
Occupational asthma
Pulmonary and Respiratory Medicine
Adult
medicine.medical_specialty
Adolescent
VENTILATED CAGE SYSTEMS
Animal Technicians
03 medical and health sciences
Young Adult
Internal medicine
Animals
Laboratory
Hypersensitivity
RODENTS
Animals
Humans
EXPOSURE
Occupational Health
Skin Tests
Science & Technology
business.industry
Laboratory animal allergy
Allergens
medicine.disease
United Kingdom
Ventilation
Rats
030228 respiratory system
biology.protein
business
Zdroj: The European respiratory journal. 53(6)
ISSN: 1399-3003
Popis: BackgroundHistorical data suggest 15% of laboratory animal workers develop IgE sensitisation and 10% symptoms of laboratory animal allergy (LAA), including occupational asthma. Individually ventilated cages (IVCs) are replacing conventional open cages; we sought to evaluate their impact on the development of LAA.MethodsWe surveyed 750 laboratory animal workers and measured airborne Mus m 1 (mouse allergen) levels in seven UK institutions. We compared the prevalence of sensitisation to mouse proteins (by specific IgE assay or skin prick test) and of work-related allergic symptoms in IVC-only and open cage units.ResultsFull-shift Mus m 1 levels were lower in IVC than open cage units (geometric mean 1.00 (95% CI 0.73–1.36) versus 8.35 (95% CI 6.97–9.95) ng·m−3; p−3). Primary analyses on data from 216 participants with ≤3 years exposure to mice revealed a lower prevalence of sensitisation in those working in IVC units compared with conventional cage units (2.4% (n=2) versus 9.8% (n=13); p=0.052). Sensitisation in IVC units varied from 0% to 12.5%; the use of fitted respiratory protection was less common in IVC units where prevalence of sensitisation was higher. Work-related allergy symptoms were more frequently reported by mouse-sensitised individuals (46.7% versus 10.9%; pConclusionIn contemporary practice, LAA is now largely preventable with the use of IVC systems and the judicious use of appropriate respiratory protection.
Databáze: OpenAIRE
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