A waterborne outbreak with a single clone of Campylobacter jejuni in the Danish town of Køge in May 2010
| Autor: | Steen Ethelberg, Line Wilchen Hollesen, Jørgen Engberg, Marianne Adelhardt, Jonas T. Larsson, P Ingildsen, Kåre Mølbak, Steen Muchitsch, Katrin Gaardbo Kuhn, Sophie-Madeleine Gubbels |
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| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
Adult Male Veterinary medicine medicine.medical_specialty Adolescent Denmark medicine.disease_cause Campylobacter jejuni Microbiology Disease Outbreaks Danish Cohort Studies Tap water Epidemiology Campylobacter Infections medicine Odds Ratio Humans Child Aged Aged 80 and over General Immunology and Microbiology biology Campylobacter Drinking Water Outbreak Infant General Medicine Middle Aged biology.organism_classification language.human_language Infectious Diseases Enterococcus Child Preschool Multivariate Analysis language Waterborne pathogen Female Flagellin |
| Zdroj: | Scandinavian journal of infectious diseases. 44(8) |
| ISSN: | 1651-1980 |
| Popis: | In Denmark, large-scale waterborne outbreaks are rare. This report describes the investigation of an outbreak that occurred in the town of Køge in May 2010.The epidemiological investigation consisted of hypothesis generating telephone interviews, followed by a cohort study among approximately 20,000 residents using an online questionnaire. Odds ratios were calculated for exposures including the number of glasses of tap water consumed. Geographical spreading was assessed using a geographical information system. The microbiological investigation included cultures of stool samples and flagellin-typing. In the environmental investigation, water samples were tested for Escherichia coli and coliform counts and for DNA of Campylobacter, Enterococcus, and Bacteroides. During the outbreak investigation a water boiling order was enforced, as tap water was considered a potential source.Of 45 patients with laboratory confirmed Campylobacter infection in the municipality of Køge in May, 43 lived in the area covered by the central water supply. Of 61 patients with laboratory confirmed Campylobacter jejuni by 8 June, 50 shared a common flagellin gene type--flaA type 36 (82%). The epidemic curve from the cohort study showed a wave of diarrhoea onset from 14 to 20 May (n = 176). Among these patients, the development of diarrhoea was associated with drinking tap water with a dose-response pattern (linear increase by 2 glasses: odds ratio 1.40, 95% confidence interval 1.16-1.70). No bacterial DNA was found in water samples.These findings indicated a point source contamination of tap water with a single clone of C. jejuni which likely occurred on 12-13 May. The water boiling order was lifted on 18 June. |
| Databáze: | OpenAIRE |
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