The emerging role of ferroptosis in intestinal disease
Autor: | Lihui Lin, Shenghong Zhang, Minhu Chen, Shu Xu, Peng Chen, Yao He |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Cell death
Cancer Research Programmed cell death Colorectal cancer Immunology Disease Review Article Inflammatory bowel disease Lipid peroxidation Cellular and Molecular Neuroscience chemistry.chemical_compound Medicine Ferroptosis Humans lcsh:QH573-671 business.industry lcsh:Cytology Cancer Cell Biology medicine.disease Intestinal epithelium Intestinal Diseases chemistry Cancer research business |
Zdroj: | Cell Death and Disease, Vol 12, Iss 4, Pp 1-12 (2021) Cell Death & Disease |
ISSN: | 2041-4889 |
Popis: | Ferroptosis is a newly recognised type of regulated cell death (RCD) characterised by iron-dependent accumulation of lipid peroxidation. It is significantly distinct from other RCDs at the morphological, biochemical, and genetic levels. Recent reports have implicated ferroptosis in multiple diseases, including neurological disorders, kidney injury, liver diseases, and cancer. Ferroptotic cell death has also been associated with dysfunction of the intestinal epithelium, which contributes to several intestinal diseases. Research on ferroptosis may provide a new understanding of intestinal disease pathogenesis that benefits clinical treatment. In this review, we provide an overview of ferroptosis and its underlying mechanisms, then describe its emerging role in intestinal diseases, including intestinal ischaemia/reperfusion (I/R) injury, inflammatory bowel disease (IBD), and colorectal cancer (CRC). |
Databáze: | OpenAIRE |
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