Diamond-Blackfan syndrome and neutropenia
| Autor: | D. I. K. Evans, K. P. Schofield |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Myeloid Neutropenia Gastroenterology Pathology and Forensic Medicine Congenital hypoplastic anaemia Bone Marrow Internal medicine hemic and lymphatic diseases medicine Humans business.industry Platelet Count Incidence (epidemiology) Infant Newborn Anemia Aplastic General Medicine Syndrome medicine.disease Surgery Blackfan-Diamond Disease Blood Cell Count medicine.anatomical_structure Female Bone marrow Complication business Diamond-Blackfan syndrome Granulocytes Research Article |
| Zdroj: | Journal of clinical pathology. 44(9) |
| ISSN: | 0021-9746 |
| Popis: | Neutropenia is a rare complication of Diamond-Blackfan syndrome (congenital hypoplastic anaemia). Three patients are reported: all had neutropenia as well as anaemia, and to investigate the cause of the neutropenia culture of bone marrow for granulocyte-macrophage colony forming cells (GMCFCs) was performed. Two cases had a low incidence of GMCFCs, but the third case had a high incidence. These findings suggest that myeloid precursors can be abnormal in Diamond-Blackfan syndrome and that the mechanism of neutropenia may, like that of anaemia, vary from patient to patient. |
| Databáze: | OpenAIRE |
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