Presence & mobility of antimicrobial resistance in Gram-negative bacteria from environmental samples in coastal Karnataka, India

Autor: Rajeshwari Vittal, Juliet Roshini Mohan Raj, Indrani Karunasagar, Anirban Chakraborty, Vijaya Kumar Deekshit, Santhosh Kogaluru Shivakumaraswamy
Rok vydání: 2019
Předmět:
prophage induction
0301 basic medicine
Gram-negative bacteria
Gene Transfer
Horizontal
Antimicrobial resistance - environment - mobile genetic elements - prophage induction
medicine.drug_class
Tetracycline
030106 microbiology
Antibiotics
India
lcsh:Medicine
Microbial Sensitivity Tests
Antimicrobial resistance
beta-Lactamases
General Biochemistry
Genetics and Molecular Biology
Microbiology
03 medical and health sciences
0302 clinical medicine
Antibiotic resistance
Plasmid
Drug Resistance
Bacterial
Gram-Negative Bacteria
Environmental Microbiology
medicine
Animals
Humans
030212 general & internal medicine
biology
lcsh:R
mobile genetic elements
Bacterial Infections
General Medicine
biology.organism_classification
Antimicrobial
Anti-Bacterial Agents
Multiple drug resistance
Original Article
environment
Bacteria
Plasmids
medicine.drug
Zdroj: Indian Journal of Medical Research, Vol 149, Iss 2, Pp 290-294 (2019)
The Indian Journal of Medical Research
ISSN: 0971-5916
DOI: 10.4103/ijmr.ijmr_2088_17
Popis: To understand antimicrobial resistance (AMR) patterns and mechanisms of horizontal gene transfer in human-associated environments is essential to AMR surveillance. Gram-negative bacteria (1122 isolates) from food-animal environments were characterized for antimicrobial susceptibility and AMR genes. Seventy five per cent of the isolates (837 of 1122) were resistant to at least one of the antibiotics tested. Resistance to more than three groups of antimicrobials (multidrug resistance) was observed in 43 isolates with most often encountered (12 of 43) resistance to β-lactams, tetracycline, quinolones and nitrofurantoin. The profile of frequently reported plasmid-mediated resistance gene in these isolates was determined. The mobility of these elements as plasmids or phages was examined. The blaCTX-M gene was present in the plasmid of 61 per cent and packed in induced phage fractions in 72 per cent of the isolates and blaTEM in 69 per cent phage fractions compared to 15 per cent presence in the plasmid.
Databáze: OpenAIRE
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