Prevention ofHaemophilus influenzaeType b Colonization by Vaccination: Correlation with Serum Anti‐Capsular IgG Concentration
| Autor: | Jacqueline Sánchez, Sharon Balter, Josefina Fernández, Jesús M. Feris, Leslye LaClaire, Sandra Romero-Steiner, Orin S. Levine |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Haemophilus Infections
Prevalence Biology medicine.disease_cause complex mixtures Immunoglobulin G Microbiology Haemophilus influenzae Conjugate vaccine medicine Humans Immunology and Allergy Colonization Bacterial Capsules Haemophilus Vaccines Polysaccharides Bacterial Vaccination Pasteurellaceae Infant bacterial infections and mycoses biology.organism_classification Antibodies Bacterial carbohydrates (lipids) Infectious Diseases Immunization Immunology biology.protein bacteria |
| Zdroj: | The Journal of Infectious Diseases. 182:1553-1556 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/315870 |
| Popis: | Concentrations of serum anti-Haemophilus influenzae type b (anti-Hib) capsular polysaccharide (CPS) >/=0.15 and >/=1.0 microgram/mL are widely used as surrogates for protection against invasive Hib disease. However, the relationship between serum anti-Hib CPS following immunization and protection against colonization is not known, making it difficult to evaluate new Hib vaccines or combination vaccines. In the Dominican Republic, nasopharyngeal swabs were collected from 546 9-month-old infants who had received Hib conjugate vaccine at ages 2, 4, and 6 months and from 600 unvaccinated infants of the same age. The prevalence of Hib colonization was lower among vaccinated infants than among unvaccinated infants (0.9% vs. 2.3%). Among vaccinated infants, protection against colonization was significantly correlated with anti-Hib CPS concentrations >/=5 microgram/mL 1 month following the third dose of vaccine. These results suggest that the concentration of serum anti-Hib CPS needed for protection against colonization is greater than that needed for protection for invasive disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|