Use of Oxygen Scavengers to Stabilize Solid Pharmaceutical Dosage Forms: A Case Study

Autor:	Kenneth Craig Waterman, Michael Christopher Roy
Rok vydání:	2002
Předmět:	Active ingredient Antioxidant Stereochemistry medicine.medical_treatment Pharmaceutical Science chemistry.chemical_element General Medicine Polyethylene Combinatorial chemistry Oxygen Dosage form chemistry.chemical_compound Drug Stability chemistry medicine Degradation (geology) Drug packaging Drug Packaging Tablets Oxygen scavenger
Zdroj:	Pharmaceutical Development and Technology. 7:227-234
ISSN:	1097-9867 1083-7450
Popis:	A case study is described where degradation of a solid pharmaceutical dosage form susceptible to oxidation is minimized by incorporation of an oxygen scavenger as part of the packaging. Extremely low oxygen levels are attainable within 24 hr of packaging, even with permeable high-density polyethylene bottles commonly used in the pharmaceutical industry. This packaging methodology allows for a practical formulation-independent pathway for reducing or eliminating oxidative instability. In addition, this technology provides a convenient mechanistic probe for the degradation mechanism of solid dosage forms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a726dc91016f13ef614e56f5bb8f6cc https://doi.org/10.1081/pdt-120003490 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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