| Popis: |
IN previous communications from this laboratory, the synthesis of urea-14C from arginine-14C was reported to occur in the living rat brain1,2. In these experiments only the rat brains were analysed for their radioactive urea content, and the objection was raised that perhaps these levels did not indicate endogenous brain urea synthesis, but were merely a reflexion of blood 14C-urea levels, especially since it is known that urea readily diffuses across the blood brain barrier. Experiments were therefore designed to show that the brain 14C-urea levels were independent of blood 14C-urea levels and that the brain had the capacity to synthesize urea from arginine. This communication describes such experiments. |
