Additional file 1 of Pharmacological modulation of Kv1.3 potassium channel selectively triggers pathological B lymphocyte apoptosis in vivo in a genetic CLL model

Autor: Severin, Filippo, Urbani, Andrea, Varanita, Tatiana, Bachmann, Magdalena, Azzolini, Michele, Martini, Veronica, Pizzi, Marco, Tos, Angelo Paolo Dei, Frezzato, Federica, Mattarei, Andrea, Ghia, Paolo, Bertilaccio, Maria Teresa Sabrina, Gulbins, Erich, Paradisi, Cristina, Zoratti, Mario, Semenzato, Gianpietro Carlo, Leanza, Luigi, Trentin, Livio, Szab��, Ildiko
Rok vydání: 2022
DOI: 10.6084/m9.figshare.19185773.v1
Popis: Additional file 1: Supplementary Figure 1. Kaplan-Meier Estimates. of the probability of developing disease during the life span of E��-TCL1 mice. Supplementary Figure 2. Flow cytometric panels showing the gating strategy. Supplementary Figure 3. Histological features of spleens from E��-TCL1 mice with no splenomegaly. Supplementary Figure 4. Residual CLL cells from PAPTP-treated E��-TCL1 mice respond to PAPTP treatment in ex vivo setting. Supplementary Figure 5. Expression of KCa3.1 channel in mitochondria of human B-CLL cells and effect of TRAM-34 on death. Supplementary Figure 6. Effect of TRAM-34 on proliferation and survival of B-CLL cells from E��-TCL1 mice. Supplementary Figure 7. PAPTP does not induce ROS release and mitochondrial depolarization in B lymphocytes of healthy subjects.
Databáze: OpenAIRE