T2- and diffusion-weighted magnetic resonance imaging of a focal ischemic lesion in rat brain
| Autor: | J E Cremer, M Doran, B M Cullen, M. D. King, Stephen R. Williams, David G. Gadian, N. Van Bruggen |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Pathology medicine.medical_specialty Ischemia Brain Ischemia Lesion Spin–spin relaxation chemistry.chemical_compound Nuclear magnetic resonance Cortex (anatomy) medicine Rose bengal Animals Tissue Distribution Serum Albumin Evans Blue Advanced and Specialized Nursing Staining and Labeling medicine.diagnostic_test business.industry Brain Rats Inbred Strains Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Rats Staining medicine.anatomical_structure chemistry Neurology (clinical) medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Stroke. 23:576-582 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/01.str.23.4.576 |
| Popis: | We sought to evaluate the application of T2-weighted and diffusion-weighted magnetic resonance imaging techniques in the study of a focal ischemic lesion in the rat brain. Unilateral cortical infarcts were induced using the photosensitive dye rose bengal and 560 nm light irradiation. Magnetic resonance images were recorded from a total of 11 rats at selected intervals from 1.5 hours to several days after induction of the lesion. Parallel experiments were performed in which Evans blue dye was injected into the lesioned animals either immediately after lesion induction (n = 11) or 1 hour before the animals were killed (n = 11). The second procedure was designed to show regions of blood-brain barrier permeability to plasma proteins at the time of sacrifice, whereas the first procedure showed the accumulation and subsequent dispersion of plasma protein following disruption of the blood-brain barrier. Regions of the cortex highlighted by the T2-weighted images corresponded well to the pattern of dye staining seen from the first procedure while the diffusion-weighted images showed visual correspondence with the staining pattern obtained using the second procedure. These results illustrate the complementary use of T2-weighted and diffusion-weighted magnetic resonance imaging in discerning the pathophysiology of developing lesions. |
| Databáze: | OpenAIRE |
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