Short report: evaluation of the potency and stability of a candidate vaccine against American cutaneous leishmaniasis
| Autor: | C. A. da Costa, Wilson Mayrink, Josué Pinto, Vinícius Nogueira Toledo, O. Genaro, Tânia Mara Pinto Dabés Guimarães, L Vilela |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Protozoan Vaccines Drug Storage Leishmaniasis Cutaneous Enzyme-Linked Immunosorbent Assay Biology Interferon-gamma Cutaneous leishmaniasis Double-Blind Method Drug Stability Virology medicine Potency Humans Leishmania amazonensis Immunogenicity American cutaneous leishmaniasis Leishmaniasis Report evaluation medicine.disease Leishmania biology.organism_classification Infectious Diseases Vaccines Inactivated Immunology Parasitology Female Brazil |
| Zdroj: | The American journal of tropical medicine and hygiene. 61(2) |
| ISSN: | 0002-9637 |
| Popis: | Availability of a safe, immunogenic, and affordable vaccine would represent the best strategy for control of cutaneous leishmaniasis (CL). Stability in field conditions is a essential property for any candidate vaccine. The stability and immunogenicity of three different preparations (thimerosal-preserved, autoclaved, and lyophilized) of a killed Leishmania amazonensis vaccine were assessed using fresh products and after 12 months of storage at 4 degrees C. Autoclaving was associated with a time-dependent decrease in the immunogenicity of the vaccine, as measured by the leishmanin skin test and production of interferon-gamma. These findings are of importance in the decision of which preparation of candidate killed CL vaccines should move to phase III trials. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|