Quantitative cardiovascular magnetic resonance perfusion imaging identifies reduced flow reserve in microvascular coronary artery disease

Autor: Jamieson M. Bourque, Jorge A. Gonzalez, Christopher M. Kramer, Yang Yang, Frederick H. Epstein, Michael Salerno, Roshin C. Mathew, Sujith Kuruvilla, Craig H. Meyer, Pelbreton C. Balfour, Peter W. Shaw, Benjamin Zorach, Angela M. Taylor, Jonathan A. Pan
Rok vydání: 2018
Předmět:
Male
Computed Tomography Angiography
Vasodilator Agents
Perfusion scanning
Coronary Artery Disease
030204 cardiovascular system & hematology
Coronary Angiography
Left ventricular hypertrophy
030218 nuclear medicine & medical imaging
Coronary artery disease
Angina
0302 clinical medicine
Medicine
2. Zero hunger
education.field_of_study
Radiological and Ultrasound Technology
medicine.diagnostic_test
Diabetes
Myocardial Perfusion Imaging
Middle Aged
Metabolic syndrome
Coronary Vessels
Microvascular disease
3. Good health
Fractional Flow Reserve
Myocardial
Myocardial perfusion reserve
cardiovascular system
Cardiology
Female
Cardiology and Cardiovascular Medicine
Perfusion
Blood Flow Velocity
medicine.drug
Adult
medicine.medical_specialty
Population
Magnetic Resonance Imaging
Cine
03 medical and health sciences
Predictive Value of Tests
Coronary Circulation
Internal medicine
Humans
Women
Radiology
Nuclear Medicine and imaging
cardiovascular diseases
education
Aged
business.industry
Research
Microcirculation
Magnetic resonance imaging
medicine.disease
Regadenoson
Purines
Case-Control Studies
Pyrazoles
Cardiovascular magnetic resonance
Non-obstructive coronary artery disease
business
Zdroj: Journal of Cardiovascular Magnetic Resonance
ISSN: 1532-429X
DOI: 10.1186/s12968-018-0435-1
Popis: Background Preliminary semi-quantitative cardiovascular magnetic resonance (CMR) perfusion studies have demonstrated reduced myocardial perfusion reserve (MPR) in patients with angina and risk factors for microvascular disease (MVD), however fully quantitative CMR has not been studied. The purpose of this study is to evaluate whether fully quantitative CMR identifies reduced MPR in this population, and to investigate the relationship between epicardial atherosclerosis, left ventricular hypertrophy (LVH), extracellular volume (ECV), and perfusion. Methods Forty-six patients with typical angina and risk factors for MVD (females, or males with diabetes or metabolic syndrome) who had no obstructive coronary artery disease by coronary angiography and 20 healthy control subjects underwent regadenoson stress CMR perfusion imaging using a dual-sequence quantitative spiral pulse sequence to quantify MPR. Subjects also underwent T1 mapping to quantify ECV, and computed tomographic (CT) coronary calcium scoring to assess atherosclerosis burden. Results In patients with risk factors for MVD, both MPR (2.21 [1.95,2.69] vs. 2.93 [2.763.19], p
Databáze: OpenAIRE
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