Temporal correlations among functionally specialized striatal neural ensembles in reward-conditioned mice
| Autor: | Sotiris C. Masmanidis, Peyman Golshani, Victor Mac, Konstantin I. Bakhurin |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Physiology Conditioning Classical Striatum Medium spiny neuron Mice 03 medical and health sciences Discrimination Psychological 0302 clinical medicine Reward Basal ganglia Animals Reward learning Neurons General Neuroscience Network dynamics Corpus Striatum Associative learning Mice Inbred C57BL 030104 developmental biology nervous system Inhibitory modulation Cues Control of Movement Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurophysiology. 115:1521-1532 |
| ISSN: | 1522-1598 0022-3077 |
| DOI: | 10.1152/jn.01037.2015 |
| Popis: | As the major input to the basal ganglia, the striatum is innervated by a wide range of other areas. Overlapping input from these regions is speculated to influence temporal correlations among striatal ensembles. However, the network dynamics among behaviorally related neural populations in the striatum has not been extensively studied. We used large-scale neural recordings to monitor activity from striatal ensembles in mice undergoing Pavlovian reward conditioning. A subpopulation of putative medium spiny projection neurons (MSNs) was found to discriminate between cues that predicted the delivery of a reward and cues that predicted no specific outcome. These cells were preferentially located in lateral subregions of the striatum. Discriminating MSNs were more spontaneously active and more correlated than their nondiscriminating counterparts. Furthermore, discriminating fast spiking interneurons (FSIs) represented a highly prevalent group in the recordings, which formed a strongly correlated network with discriminating MSNs. Spike time cross-correlation analysis showed the existence of synchronized activity among FSIs and feedforward inhibitory modulation of MSN spiking by FSIs. These findings suggest that populations of functionally specialized (cue-discriminating) striatal neurons have distinct network dynamics that sets them apart from nondiscriminating cells, potentially to facilitate accurate behavioral responding during associative reward learning. |
| Databáze: | OpenAIRE |
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