Glucose Metabolism Disorder Induces Spermatogenic Dysfunction in Northern Pig-Tailed Macaques (Macaca leonina) With Long-Term SIVmac239 Infection
| Autor: | Ren-Rong Tian, Yong-Tang Zheng, Wei Pang, Ming-Xu Zhang, Tian-Zhang Song, Han-Dan Zhang, Xue-Hui Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
endocrine system medicine.medical_specialty glucose metabolism Endocrinology Diabetes and Metabolism Simian Acquired Immunodeficiency Syndrome Carbohydrate metabolism Biology medicine.disease_cause Diseases of the endocrine glands. Clinical endocrinology Cachexia Macaca leonina Follicle-stimulating hormone Endocrinology Glucose Metabolism Disorder Insulin-Secreting Cells Internal medicine medicine Animals Insulin Spermatogenesis Infertility Male Original Research Glucose Metabolism Disorders Hormone Imbalance geography geography.geographical_feature_category Simian immunodeficiency virus RC648-665 northern pig-tailed macaques Sertoli cell Islet medicine.disease Semen Analysis Glucose medicine.anatomical_structure SIVmac239 spermatogenic dysfunction Simian Immunodeficiency Virus Macaca nemestrina |
| Zdroj: | Frontiers in Endocrinology Frontiers in Endocrinology, Vol 12 (2021) |
| ISSN: | 1664-2392 |
| DOI: | 10.3389/fendo.2021.745984 |
| Popis: | Although spermatogenic dysfunction is widely found in patients with human immunodeficiency virus (HIV), the underlying reasons remain unclear. Thus far, potential hypotheses involving viral reservoirs, testicular inflammation, hormone imbalance, and cachexia show inconsistent correlation with spermatogenic dysfunction. Here, northern pig-tailed macaques (NPMs) exhibited marked spermatogenic dysfunction after long-term infection with simian immunodeficiency virus (SIVmac239), with significant decreases in Johnsen scores, differentiated spermatogonial stem cells, and testicular proliferating cells. The above hypotheses were also evaluated. Results showed no differences between SIV− and SIV+ NPMs, except for an increase in follicle stimulating hormone (FSH) during SIV infection, which had no direct effect on the testes. However, long-term SIVmac239 infection undermined pancreatic islet β cell function, partly represented by significant reductions in cellular counts and autophagy levels. Pancreatic islet β cell dysfunction led to glucose metabolism disorder at the whole-body level, which inhibited lactate production by Sertoli cells in testicular tissue. As lactate is the main energy substrate for developing germ cells, its decrease was strongly correlated with spermatogenic dysfunction. Therefore, glucose metabolism disorder appears to be a primary cause of spermatogenic dysfunction in NPMs with long-term SIVmac239 infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|