A study of theIn Vivo activity of the leaf extract ofAlchornea cordifolia against multiply antibiotic resistantS. aureus isolate in mice
| Autor: | Ezekiel Olugbenga Iwalewa, Adebayo Lamikanra, O. A. Igbeneghu |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Staphylococcus aureus Alchornea cordifolia medicine.drug_class Antibiotics Microbial Sensitivity Tests Pharmacognosy medicine.disease_cause Median lethal dose Microbiology Mice In vivo medicine Animals Antibacterial agent Pharmacology biology Plant Extracts Euphorbiaceae biology.organism_classification Anti-Bacterial Agents Plant Leaves Female Methicillin Resistance Antibacterial activity Phytotherapy |
| Zdroj: | Phytotherapy Research. 21:67-71 |
| ISSN: | 1099-1573 0951-418X |
| DOI: | 10.1002/ptr.2003 |
| Popis: | The effect of a 50% aqueous ethanol extract of Alchornea cordifolia (Schum and Thonn) Muell. Arg. leaf was investigated in mice which had been infected intraperitoneally with 5.0 × 109 cfu of Staphylococcus aureus. Dose-dependent antibacterial activity was demonstrated and the rate of survival of infected mice was improved significantly by doses between 25 and 200 mg/kg of injected extract when compared with untreated infected controls. The intraperitoneal median lethal dose of the extract was found to be 800 mg/kg. Copyright © 2006 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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