Exercise testing for long-term follow-up in arrhythmogenic right ventricular cardiomyopathy
| Autor: | Agota Alfoldine Ando, Jan Engvall, Daniel Karlsson, Meriam Åström Aneq |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Long term follow up Physical exercise 030204 cardiovascular system & hematology Sensitivity and Specificity Right ventricular cardiomyopathy 03 medical and health sciences Electrocardiography 0302 clinical medicine Internal medicine Medicine Humans In patient cardiovascular diseases 030212 general & internal medicine Longitudinal Studies Arrhythmogenic Right Ventricular Dysplasia Peak exercise Exercise Tolerance medicine.diagnostic_test business.industry Reproducibility of Results Prognosis Physical work cardiovascular system Cardiology Exercise Test Female Ventricular ectopic activity Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Journal of electrocardiology. 50(2) |
| ISSN: | 1532-8430 |
| Popis: | Objectives We investigated arrhythmia, electrocardiography and physical work capacity (PWC) in the follow-up of ARVC. Design Twenty-three patients (13 men; age 41±12years) fulfilling diagnostic criteria were re-investigated after at least five years. Results Ventricular arrhythmia during exercise testing (ET) was present in 14 patients (61%) and showed variation between examinations. In eleven (48%), complex ventricular ectopic activity was observed at peak exercise or immediately thereafter. Mutations known to be pathogenic in ARVC were present in 13 patients (57%) of which 11 developed complex ventricular arrhythmia at ET. PWC at baseline was 190±66W (104±26%) decreasing to 151±61W (91±23%, p =0.008) after 10.7years. Conclusion The appearance of ventricular arrhythmia during exercise testing showed temporal variation but was frequent in patients with relevant genetic mutation. Physical exercise capacity decreased over time in patients with ARVC in excess to the age-related deterioration and regardless of medication. |
| Databáze: | OpenAIRE |
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