Abnormalities in Chromosomes 1q and 13 Independently Correlate With Factors of Poor Prognosis in Multiple Myeloma

Autor: Young Kyung Lee, Young Su Ju, Hee Jung Kang, Jung Ah Kim, Han Sung Kim, Hyoun Chan Cho, Eun Jin Lee, Hyo Jung Kim, Dong Soon Lee, Miyoung Kim
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Clinical Biochemistry
Myeloma
Gastroenterology
Pathogenesis
Hemoglobins
chemistry.chemical_compound
0302 clinical medicine
Multiple myeloma
Aged
80 and over
Clinical pathology
Karyotype
General Medicine
Middle Aged
Prognosis
Survival Rate
Chromosomes
Human
Pair 1
030220 oncology & carcinogenesis
Female
Original Article
Chromosomes
Human
Pair 4
Multiple Myeloma
Adult
medicine.medical_specialty
Adolescent
Chromosome
Creatine
Young Adult
03 medical and health sciences
Internal medicine
medicine
Humans
Survival analysis
Aged
Chromosome 13
Chromosome Aberrations
Chromosomes
Human
Pair 13
business.industry
Biochemistry (medical)
medicine.disease
Immunoglobulin A
030104 developmental biology
chemistry
Immunoglobulin G
Karyotyping
Multivariate Analysis
Calcium
business
Diagnostic Genetics
Zdroj: Annals of Laboratory Medicine
ISSN: 2234-3814
2234-3806
DOI: 10.3343/alm.2016.36.6.573
Popis: Background We comprehensively profiled cytogenetic abnormalities in multiple myeloma (MM) and analyzed the relationship between cytogenetic abnormalities of undetermined prognostic significance and established prognostic factors. Methods The karyotype of 333 newly diagnosed MM cases was analyzed in association with established prognostic factors. Survival analysis was also performed. Results MM with abnormal karyotypes (41.1%) exhibited high international scoring system (ISS) stage, frequent IgA type, elevated IgG or IgA levels, elevated calcium levels, elevated creatine (Cr) levels, elevated β2-microglobulin levels, and decreased Hb levels. Structural abnormalities in chromosomes 1q, 4, and 13 were independently associated with elevated levels of IgG or IgA, calcium, and Cr, respectively. Chromosome 13 abnormalities were associated with poor prognosis and decreased overall survival. Conclusions This is the first study to demonstrate that abnormalities in chromosomes 1q, 4, and 13 are associated with established factors for poor prognosis, irrespective of the presence of other concurrent chromosomal abnormalities. Chromosome 13 abnormalities have a prognostic impact on overall survival in association with elevated Cr levels. Frequent centromeric breakpoints appear to be related to MM pathogenesis.
Databáze: OpenAIRE
Externí odkaz: