Reduction Mechanisms of Anticancer Osmium(VI) Complexes Revealed by Atomic Telemetry and Theoretical Calculations
| Autor: | Jakub Szlachetko, Gilles Berger, Jacinto Sá, Anna Wach |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
inorganic chemicals
Reducing agent chemistry.chemical_element Antineoplastic Agents Chimie inorganique 010402 general chemistry Photochemistry 01 natural sciences Chemical reaction Inorganic Chemistry Reduction (complexity) Metal Physico-chimie générale Coordination Complexes Osmium Emission spectrum Physical and Theoretical Chemistry Density Functional Theory Molecular Structure 010405 organic chemistry Chemistry Spectrometry X-Ray Emission Chimie théorique 0104 chemical sciences Chemical state visual_art visual_art.visual_art_medium Oxidation-Reduction In situ study |
| Zdroj: | Inorganic chemistry, 60 |
| ISSN: | 1520-510X 0020-1669 |
| Popis: | Resonant X-ray emission spectroscopy (RXES) has developed in the past decade as a powerful tool to probe the chemical state of a metal center and in situ study chemical reactions. We have used it to monitor spectral changes associated with the reduction of osmium(VI) nitrido complexes to the osmium(III) ammine state by the biologically relevant reducing agent, glutathione. RXES difference maps are consistent with the proposed DFT mechanism and the formation of two stable osmium(IV) intermediates, thereby supporting the overall pathway for the reduction of these high-valent anticancer metal complexes for which reduction by thiols within cells may be essential to the antiproliferative activity. SCOPUS: ar.j info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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