Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity
Autor: | Guan-Jhong Huang, Amooru G. Damu, Yu Yi Chan, Tian Shung Wu, Ping Chung Kuo, Shin-Hun Juang, De Yang Shen |
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Rok vydání: | 2012 |
Předmět: |
Lipopolysaccharides
Chemical transformation Cell Survival medicine.drug_class Proton Magnetic Resonance Spectroscopy Flavonoid Anti-Inflammatory Agents Andrographis echioides Nitric Oxide Article Catalysis Anti-inflammatory Cell Line lcsh:Chemistry Inorganic Chemistry Mice Tandem Mass Spectrometry flavonoid anti-inflammatory iNOS medicine Animals Spectral analysis Carbon-13 Magnetic Resonance Spectroscopy Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Spectroscopy chemistry.chemical_classification Traditional medicine business.industry Organic Chemistry food and beverages Glycoside General Medicine Flavones Computer Science Applications lcsh:Biology (General) lcsh:QD1-999 chemistry Phytochemical Chemical constituents Flavanones Macrophages Peritoneal Andrographis business Chromatography Liquid |
Zdroj: | International Journal of Molecular Sciences; Volume 14; Issue 1; Pages: 496-514 International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 14, Iss 1, Pp 496-514 (2012) |
ISSN: | 1422-0067 |
Popis: | Phytochemical investigation of the whole plants of Andrographis echioides afforded two new 2'-oxygenated flavonoids (1) and (2), two new phenyl glycosides (3) and (4), along with 37 known structures. The structures of new compounds were elucidated by spectral analysis and chemical transformation studies. Among the isolated compounds, (1–2) and (6–19) were subjected into the examination for their iNOS inhibitory bioactivity. The structure-activity relationships of the flavonoids for their inhibition of NO production were also discussed. |
Databáze: | OpenAIRE |
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