Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity

Autor: Guan-Jhong Huang, Amooru G. Damu, Yu Yi Chan, Tian Shung Wu, Ping Chung Kuo, Shin-Hun Juang, De Yang Shen
Rok vydání: 2012
Předmět:
Lipopolysaccharides
Chemical transformation
Cell Survival
medicine.drug_class
Proton Magnetic Resonance Spectroscopy
Flavonoid
Anti-Inflammatory Agents
Andrographis echioides
Nitric Oxide
Article
Catalysis
Anti-inflammatory
Cell Line
lcsh:Chemistry
Inorganic Chemistry
Mice
Tandem Mass Spectrometry
flavonoid
anti-inflammatory
iNOS
medicine
Animals
Spectral analysis
Carbon-13 Magnetic Resonance Spectroscopy
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Molecular Biology
Spectroscopy
chemistry.chemical_classification
Traditional medicine
business.industry
Organic Chemistry
food and beverages
Glycoside
General Medicine
Flavones
Computer Science Applications
lcsh:Biology (General)
lcsh:QD1-999
chemistry
Phytochemical
Chemical constituents
Flavanones
Macrophages
Peritoneal
Andrographis
business
Chromatography
Liquid
Zdroj: International Journal of Molecular Sciences; Volume 14; Issue 1; Pages: 496-514
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 14, Iss 1, Pp 496-514 (2012)
ISSN: 1422-0067
Popis: Phytochemical investigation of the whole plants of Andrographis echioides afforded two new 2'-oxygenated flavonoids (1) and (2), two new phenyl glycosides (3) and (4), along with 37 known structures. The structures of new compounds were elucidated by spectral analysis and chemical transformation studies. Among the isolated compounds, (1–2) and (6–19) were subjected into the examination for their iNOS inhibitory bioactivity. The structure-activity relationships of the flavonoids for their inhibition of NO production were also discussed.
Databáze: OpenAIRE
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