Does therapeutic plasma exchange have a role in resistant cytokine storm state of COVID-19 infection?
| Autor: | Ehab M. El-Reweny, Nermine Hossam Zakaria, Akram Mohamed Fayed, Ayman Ibrahim Baess, Mohamed Mamdouh Elsayed, Montasser M Zeid |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19) business.industry animal diseases Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Treatment options General Medicine medicine.disease Immunology Medicine Therapeutic plasma exchange COVID-19 cytokine storm therapeutic plasma exchange TPE business Cytokine storm |
| Zdroj: | Alexandria Journal of Medicine; Vol. 57 No. 1 (2021); 235-239 |
| ISSN: | 1110-0834 2090-2948 |
| Popis: | Introduction: Among the main causes of mortality in COVID-19 patients is cytokine storm (CS) state. Few treatment options with variable efficacy results are available for its management. We aimed to illustrate the efficacy of Therapeutic Plasma Exchange (TPE) treatment in COVID-19 patients with resistant CS.Material and methods: This research is a prospective pilot study which included ten COVID-19 positive patients with CS state with no response after two doses of tocilizumab. Each patient received three to five TPE sessions according to his/her response. Respiratory status {oxygen (O2) requirements and data of mechanical ventilation} and laboratory markers (IL-6, CRP, ferritin, D dimer, LDH) were assessed before and after TPE. We reported mortality at 28 day of illness.Results: Six males and four females were enrolled in the study with a mean age of (52.9 years). Seven patients (70%) were on mechanical ventilation (MV). After TPE, oxygenation parameters and most laboratory markers improved significantly in all patients (p < 0.05). Four patients survived and were discharged (40%). One was on MV and three were not. The four patients had better hypoxic index (PaO2/FiO2 ratio) (˃100 vs |
| Databáze: | OpenAIRE |
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