Current uncertainties and future challenges regarding NAD+ boosting strategies
| Autor: | Borut Poljšak, Vito Kovač, Irina Milisav |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
safety
NAD+ ojačevalci Physiology NAD+ boosters NAD+ precursors Clinical Biochemistry udc:613.98:616-092:66.094.3.097.8 Cell Biology Biochemistry prekurzorji NAD+ stranski učinki side effects varnost udc:613 nikotinamid adenin dinukleotid NAD+ NAD+ ojačevalci prekurzorji NAD+ varnost stranski učinki nicotinamide adenine dinucleotide NAD+ NAD+ boosters NAD+ precursors safety side effects NAD+ nikotinamid adenin dinukleotid Molecular Biology nicotinamide adenine dinucleotide |
| Zdroj: | Antioxidants, vol. 11, no. 9, 1637, 2022. Antioxidants, str. 1-18 : ilustr., Vol. 11, iss. 9, 2022 COBISS-ID: 522976025 |
| ISSN: | 2076-3921 |
| Popis: | Precursors of nicotinamide adenine dinucleotide (NAD+), modulators of enzymes of the NAD+ biosynthesis pathways and inhibitors of NAD+ consuming enzymes, are the main boosters of NAD+. Increasing public awareness and interest in anti-ageing strategies and health-promoting lifestyles have grown the interest in the use of NAD+ boosters as dietary supplements, both in scientific circles and among the general population. Here, we discuss the current trends in NAD+ precursor usage as well as the uncertainties in dosage, timing, safety, and side effects. There are many unknowns regarding pharmacokinetics and pharmacodynamics, particularly bioavailability, metabolism, and tissue specificity of NAD+ boosters. Given the lack of long-term safety studies, there is a need for more clinical trials to determine the proper dose of NAD+ boosters and treatment duration for aging prevention and as disease therapy. Further research will also need to address the long-term consequences of increased NAD+ and the best approaches and combinations to increase NAD+ levels. The answers to the above questions will contribute to the more efficient and safer use of NAD+ boosters. Nasl. z nasl. zaslona. Opis vira z dne 25. 8. 2022. Članek št. 1637. Abstract. Bibliografija: str. 11-18. ARRS, Programi, Sl, Mehanizmi varovanja zdravja ARRS, Programi, Sl, Aplikativna in bazična fiziologija in patofiziologija v medicini |
| Databáze: | OpenAIRE |
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