Morphogenesis is transcriptionally coupled to neurogenesis during peripheral olfactory organ development

Autor: Virginie Lecaudey, Sandra Link, Pascale Dufourcq, Marion Aguirrebengoa, Patrick Blader, Raphaël Aguillon, Gill Bejerano, Harendra Guturu, Romain Madelaine, Julie Batut
Přispěvatelé: Centre de biologie du développement (CBD), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre de Biologie Intégrative (CBI), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre de Biologie Intégrative (CBI)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Olfactory system
Nervous system
Receptors
CXCR4
Embryo
Nonmammalian
[SDV]Life Sciences [q-bio]
Neurogenesis
Morphogenesis
Embryonic Development
Context (language use)
Nerve Tissue Proteins
Biology
E-Box Elements
03 medical and health sciences
0302 clinical medicine
Olfactory Mucosa
medicine
Basic Helix-Loop-Helix Transcription Factors
Animals
Molecular Biology
Transcription factor
Zebrafish
[SDV.BDD]Life Sciences [q-bio]/Development Biology
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
Neurons
0303 health sciences
Gene Expression Regulation
Developmental
[SDV.BDD.MOR]Life Sciences [q-bio]/Development Biology/Morphogenesis
Zebrafish Proteins
biology.organism_classification
Cell biology
medicine.anatomical_structure
Mutation
Transcription Initiation Site
Olfactory epithelium
030217 neurology & neurosurgery
Developmental Biology
MESH: Chemokine
Neurogenin1
Olfactory placode
Zdroj: Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2020, ⟨10.1242/dev.192971⟩
Development (Cambridge, England), Company of Biologists, 2020, pp.dev.192971. ⟨10.1242/dev.192971⟩
Development
Development, Palgrave Macmillan, 2020
ISSN: 1477-9129
1011-6370
DOI: 10.1242/dev.192971⟩
Popis: Sense organs acquire their distinctive shapes concomitantly with the differentiation of sensory cells and neurons necessary for their function. Although our understanding of the mechanisms controlling morphogenesis and neurogenesis in these structures has grown, how these processes are coordinated remains largely unexplored. Neurogenesis in the zebrafish olfactory epithelium requires the bHLH proneural transcription factor Neurogenin 1 (Neurog1). To address whether Neurog1 also controls morphogenesis, we analysed the migratory behaviour of early olfactory neural progenitors in neurog1 mutant embryos. Our results indicate that the oriented movements of these progenitors are disrupted in this context. Morphogenesis is similarly affected by mutations in the chemokine receptor gene, cxcr4b, suggesting it is a potential Neurog1 target gene. We find that Neurog1 directly regulates cxcr4b through an E-box cluster located just upstream of the cxcr4b transcription start site. Our results suggest that proneural transcription factors, such as Neurog1, directly couple distinct aspects of nervous system development.
Databáze: OpenAIRE
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