Early AGEing and metabolic diseases: is perinatal exposure to glycotoxins programming for adult-life metabolic syndrome?
| Autor: | Lucas Paulo Jacinto Saavedra, Flávio Andrade Francisco, Paulo Matafome, Marcos Divino Ferreira Junior, Paulo Cezar de Freitas Mathias, Catia Barra, Rodrigo Mello Gomes |
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| Rok vydání: | 2020 |
| Předmět: |
Glycation End Products
Advanced 0301 basic medicine Aging Medicine (miscellaneous) Disease 030204 cardiovascular system & hematology Bioinformatics 03 medical and health sciences chemistry.chemical_compound Fetus 0302 clinical medicine Insulin resistance Pregnancy Glycation medicine Animals Humans Metabolic Syndrome Nutrition and Dietetics Perinatal Exposure business.industry Methylglyoxal Infant Newborn Infant Pyruvaldehyde medicine.disease Oxidative Stress Adult life 030104 developmental biology chemistry Ageing Prenatal Exposure Delayed Effects Female Insulin Resistance Metabolic syndrome business |
| Zdroj: | Nutrition Reviews. 79:13-24 |
| ISSN: | 1753-4887 0029-6643 |
| DOI: | 10.1093/nutrit/nuaa074 |
| Popis: | Perinatal early nutritional disorders are critical for the developmental origins of health and disease. Glycotoxins, or advanced glycation end-products, and their precursors such as the methylglyoxal, which are formed endogenously and commonly found in processed foods and infant formulas, may be associated with acute and long-term metabolic disorders. Besides general aspects of glycotoxins, such as their endogenous production, exogenous sources, and their role in the development of metabolic syndrome, we discuss in this review the sources of perinatal exposure to glycotoxins and their involvement in metabolic programming mechanisms. The role of perinatal glycotoxin exposure in the onset of insulin resistance, central nervous system development, cardiovascular diseases, and early aging also are discussed, as are possible interventions that may prevent or reduce such effects. |
| Databáze: | OpenAIRE |
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