The role of Ga-68-DOTA-TATE PET/CT scanning in the evaluation of patients with multiple myeloma: preliminary results

Autor: Meltem Ocak, Reşit Akyel, Tugrul Elverdi, Betül Vatankulu, Melih Engin Erkan, Yildiz Aydin, Emre Demirci, Metin Halac, Kerim Sonmezoglu
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Adult
Male
medicine.medical_specialty
Fluorine Radioisotopes
Gallium Radioisotopes
030218 nuclear medicine & medical imaging
Lesion
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
plasmacytoma
Fluorodeoxyglucose F18
Positron Emission Tomography Computed Tomography
medicine
Organometallic Compounds
Humans
Radiology
Nuclear Medicine and imaging
Prospective Studies
Prospective cohort study
somatostatin receptor scintigraphy
Multiple myeloma
Aged
Fluorodeoxyglucose
DOTA-TATE
PET-CT
business.industry
gallium-68 DOTA-TATE
Hazard ratio
General Medicine
Middle Aged
medicine.disease
fluorine-18 fluorodeoxyglucose
multiple myeloma
medicine.anatomical_structure
PET
chemistry
030220 oncology & carcinogenesis
Female
Radiology
Bone marrow
medicine.symptom
Radiopharmaceuticals
business
medicine.drug
CT
Popis: Sonmezoglu, Kerim/0000-0003-1215-5184; Demirci, Emre/0000-0002-6387-9089; ELVERDI, TUGRUL/0000-0001-9496-5353; ocak, meltem/0000-0001-9214-3938 WOS: 000390778600011 PubMed: 27775994 ObjectiveIn this observational pilot study, we aimed to evaluate the role of gallium-68-labelled DOTA-TATE (Ga-68-TATE) PET/computed tomography (CT) scanning in patients with multiple myeloma (MM), considering previous promising results obtained from conventional somatostatin receptor scintigraphy with In-111 pentetreotide.Materials and methodsTwenty-one patients with a diagnosis of MM were prospectively included in this study: eight patients were referred for initial staging and 13 patients for restaging purpose. Both fluorine-18 fluorodeoxyglucose (F-18-FDG) and TATE PET/CT scanning were performed in all patients.ResultsAll patients had one or more PET-positive lesion on either F-18-FDG or TATE scans. Six patients had an additional diffusely increased bone marrow activity on F-18-FDG scans, five of whom also had a concordant bone marrow appearance on TATE scans. Each PET set (either F-18-FDG or TATE) was positive in 19 patients. There was a discordant result in four (19%) patients between F-18-FDG and TATE scans. F-18-FDG scans showed 112 lesions (86 TATE-positive; 26 TATE-negative) in 19 patients, whereas TATE scans showed 108 lesions (86 F-18-FDG-positive; 22 F-18-FDG-negative) in 19 patients. No significant difference was found between the two modalities in terms of lesion numbers detected (P=0.67). However, the presence of diffuse bone marrow uptake of TATE seems to be a predicting factor for the overall survival (P=0.033, hazard ratio: 15.2 and 95% confidence interval: 1.2-185.5).ConclusionTATE PET/CT seems to be an alternative imaging modality and may play a complementary role in MM management, at least by providing a different pathobiological insight into the disease.
Databáze: OpenAIRE
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