Ketoconazole-conjugated ZnO nanoparticles based semi-solid formulation and study their impacts on skin disease
| Autor: | Muthusamy Raman, Diviya Bharathi babu, Murugaiyan Latha Mala Priyadharshini, Rajasekar vaiyamalai, Gopal Dhinakarraj, Kaliyaperumal Viswanathan |
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| Rok vydání: | 2019 |
| Předmět: |
Antifungal Agents
Kinetics chemistry.chemical_element Nanoparticle Metal Nanoparticles 02 engineering and technology Zinc 010402 general chemistry 01 natural sciences Polyvinyl alcohol chemistry.chemical_compound Dogs In vivo Animals Dermatomycoses Electrical and Electronic Engineering Skin Drug Carriers Malassezia Methylparaben Penetration (firestop) 021001 nanoscience & nanotechnology 0104 chemical sciences Electronic Optical and Magnetic Materials Ketoconazole chemistry Nanomedicine Zinc Oxide 0210 nano-technology Gels Biotechnology Nuclear chemistry Research Article |
| Zdroj: | IET Nanobiotechnol |
| ISSN: | 1751-875X |
| Popis: | In this study, the ketoconazole-conjugated zinc oxide (ZnO) nanoparticles were prepared in a single-step approach using dextrose as an intermediate compound. The physical parameters confirmed the drug conjugation with ZnO and their size was around 70-75 nm. The drug loading and in vivo drug release studies indicated that the -CHO group from the dextrose increase the drug loading up to 65% and their release kinetics were also studied. The anti-fungal studies indicated that the prepared nanoparticles exhibit strong anti-fungal activity and the minimum concentration needed is 10 mg/ml. The nanoparticles loaded semi-solid gel was prepared using carbopol, methylparaben, propyl paraben and propylene glycol. The in vitro penetration of the ketoconazole-conjugated nanoparticles was studied using the skin. The results indicated that the semi-solid gel preparations influenced the penetration and also favoured the accumulation into the skin membrane. The veterinary clinical studies indicated that the prepared gel is highly suitable for treatment of Malassezia. |
| Databáze: | OpenAIRE |
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