Maternal Psychological Distress, Prenatal Cortisol, and Fetal Weight
| Autor: | Saul M. Schanberg, Nancy Aaron Jones, Maria Hernandez-Reif, Adolfo Gonzalez-Garcia, Tiffany Field, Miguel Diego, Cynthia M. Kuhn |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Hypothalamo-Hypophyseal System medicine.medical_specialty Hydrocortisone Emotions Pituitary-Adrenal System Gestational Age Anxiety Severity of Illness Index Ultrasonography Prenatal Fetal Development Norepinephrine Fetus Pregnancy Surveys and Questionnaires medicine Humans Psychological testing Psychiatry Applied Psychology Psychological Tests Anthropometry Depression business.industry Obstetrics Gestational age medicine.disease Pregnancy Complications Psychiatry and Mental health Distress Cross-Sectional Studies medicine.anatomical_structure Pregnancy Trimester Second Florida Female medicine.symptom business Stress Psychological Hypothalamic–pituitary–adrenal axis medicine.drug |
| Zdroj: | Psychosomatic Medicine. 68:747-753 |
| ISSN: | 0033-3174 |
| DOI: | 10.1097/01.psy.0000238212.21598.7b |
| Popis: | Objective The objective of this study was to examine the effects of maternal psychological distress on estimated fetal weight during midgestation and explore the maternal hypothalamic-pituitary axis and sympathoadrenal dysregulation as potential risk factors for these effects. Methods Fetal ultrasound biometry measurements and maternal sociodemographic characteristics, emotional distress symptoms, and first morning urine samples were collected during a clinical ultrasound examination for a cross-sectional sample of 98 women who were between 16 and 29 weeks pregnant. Fetal weight was estimated from ultrasound biometry measurements; maternal emotional distress was assessed using the daily hassles (stress), Center for Epidemiologic Studies-Depression (depression), and State-Trait Anxiety Inventory (anxiety) scales; and urine samples were assayed for cortisol and norepinephrine levels. Results Correlation analyses revealed that both maternal psychological (daily hassles, depression, and anxiety) and biochemical (cortisol and norepinephrine) variables were negatively related to fetal biometry measurements and estimated fetal weight. A structural equation model further revealed that when the independent variance of maternal sociodemographic, psychological distress, and biochemistry measures were accounted for, prenatal cortisol was the only significant predictor of fetal weight. Conclusions Women exhibiting psychological distress during pregnancy exhibit elevated cortisol levels during midgestation that are in turn related to lower fetal weight. |
| Databáze: | OpenAIRE |
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