Serum neurofilament light chain in pediatric MS and other acquired demyelinating syndromes
| Autor: | Annet F. Wierenga, Marie-José Melief, E. Daniëlle van Pelt, Rinze F. Neuteboom, Jens Kuhle, Christian Barro, Arlette L. Bruijstens, Yu Yi M. Wong, Rogier Q. Hintzen, Zuzanna Michalak |
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| Přispěvatelé: | Neurology, Immunology |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Multiple Sclerosis Adolescent Neurofilament light Gastroenterology Disease activity 03 medical and health sciences 0302 clinical medicine Neurofilament Proteins Internal medicine medicine Humans Prospective Studies Child Prospective cohort study business.industry Syndrome Peripheral 030104 developmental biology Multicenter study Child Preschool Female Neurology (clinical) business Biomarkers 030217 neurology & neurosurgery Demyelinating Diseases |
| Zdroj: | Neurology, 93(10), e968-e974. Lippincott Williams & Wilkins |
| ISSN: | 0028-3878 |
| DOI: | 10.1212/wnl.0000000000008057 |
| Popis: | ObjectiveTo explore the correlation between serum and CSF neurofilament light chain (NfL) and the association of NfL levels and future disease activity in pediatric patients with a first attack of acquired demyelinating syndromes (ADS).MethodsIn total, 102 children ResultsOf the 102 patients, 47 (46%) were tested for CSF NfL. CSF and serum NfL correlated significantly in the total group (ρ 0.532, p < 0.001) and even more significantly in the subgroup of patients with future CDMS diagnosis (ρ 0.773, p < 0.001). sNfL was higher in patients than in controls (geometric mean 6.1 pg/mL, p < 0.001), and was highest in ADS presenting with encephalopathy (acute disseminated encephalomyelitis, n = 28, 100.4 pg/mL), followed by patients without encephalopathy (ADS−) with future CDMS diagnosis (n = 40, 32.5 pg/mL), and ADS− who remained monophasic (n = 34, 17.6 pg/mL). sNfL levels higher than a median of 26.7 pg/mL at baseline are associated with a shorter time to CDMS diagnosis in ADS− (p = 0.045). HR for CDMS diagnosis was 1.09 for each 10 pg/mL increase of sNfL, after correction for age, oligoclonal bands, and MRI measures (p = 0.012).ConclusionThe significant correlation between CSF and serum NfL strengthens its reliability as a peripheral marker of neuroaxonal damage. Higher sNfL levels at baseline were associated with higher probability of future CDMS diagnosis in ADS−. |
| Databáze: | OpenAIRE |
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