Protective effects of seahorse extracts in a rat castration and testosterone-induced benign prostatic hyperplasia model and mouse oligospermatism model
| Autor: | Xueting Mei, Donghui Xu, Shibo Xu, Bing-Ji Li, Jun-Li Lv, Li-Hong Wang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Health Toxicology and Mutagenesis Acid Phosphatase Basic fibroblast growth factor Prostatic Hyperplasia urologic and male genital diseases Toxicology Rats Sprague-Dawley Mice chemistry.chemical_compound Prostate Proliferating Cell Nuclear Antigen Internal medicine Animals Medicine Testosterone Castration Cyclophosphamide Pharmacology Biological Products Sperm Count biology business.industry Oligospermia General Medicine Hyperplasia medicine.disease biology.organism_classification Smegmamorpha Disease Models Animal medicine.anatomical_structure Erectile dysfunction Endocrinology chemistry Seahorse Sperm Motility Finasteride Female Fibroblast Growth Factor 2 Nitric Oxide Synthase business Penis |
| Zdroj: | Environmental Toxicology and Pharmacology. 37:679-688 |
| ISSN: | 1382-6689 |
| DOI: | 10.1016/j.etap.2014.02.001 |
| Popis: | This study investigated the effects of seahorse (Hippocampus spp.) extracts in a rat model of benign prostatic hyperplasia (BPH) and mouse model of oligospermatism. Compared to the sham operated group, castration and testosterone induced BPH, indicated by increased penile erection latency; decreased penis nitric oxide synthase (NOS) activity; reduced serum acid phosphatase (ACP) activity; increased prostate index; and epithelial thickening, increased glandular perimeter, increased proliferating cell nuclear antigen (PCNA) index and upregulation of basic fibroblast growth factor (bFGF) in the prostate. Seahorse extracts significantly ameliorated the histopathological changes associated with BPH, reduced the latency of penile erection and increased penile NOS activity. Administration of seahorse extracts also reversed epididymal sperm viability and motility in mice treated with cyclophosphamide (CP). Seahorse extracts have potential as a candidate marine drug for treating BPH without inducing the side effects of erectile dysfunction (ED) or oligospermatism associated with the BPH drug finasteride. |
| Databáze: | OpenAIRE |
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