Effect of surfactants on percutaneous absorption of naproxen II: in vivo and in vitro correlations in rats

Autor:	R. Pritchard, A. Tomolonis, W.H. Rooks, Z.T. Chowhan
Rok vydání:	1978
Předmět:	Male Naproxen Chromatography Chemistry Skin Absorption Anti-Inflammatory Agents Non-Steroidal Pharmaceutical Science Absorption (skin) Pharmacology In Vitro Techniques In vitro Rats Excipients Surface-Active Agents In vivo Percutaneous absorption medicine Animals Female Antipyretic medicine.drug
Zdroj:	Journal of pharmaceutical sciences. 67(11)
ISSN:	0022-3549
Popis:	The effect of surfactants on percutaneous absorption of naproxen was studied using rat in vivo models. The in vivo normalized relative absorption rates were in good agreement with the in vitro relative flux. An antipyretic model in the rat could not show relatively small increases in percutaneous absorption caused by the surfactants. Based on these results, it is apparent that reliance on the rat, using either in vitro or in vivo models, may lead to erroneous conclusions when considering the effect of surfactants on human percutaneous absorption of drugs such as naproxen.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a577073ead3ffa4c48c3e12b97e356f https://pubmed.ncbi.nlm.nih.gov/309506 Zobrazit plný text záznamu Plný text