Dopamine-mediated effects induced by metoclopramide simultaneously on adrenocorticotropic hormone and prolactin in patients with pituitary and/or hypothalamic disorders
| Autor: | Ryoji Ishii, Hideki Oyama, Youjiro Kawai, Kou Tsushima, Masaharu Horino, Masaya Yoneda, Michihiro Matsuki, Seikoh Nishida |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Hydrocortisone Metoclopramide Dopamine Pituitary Diseases Clinical Biochemistry Adrenocorticotropic hormone Biochemistry Hypothalamic disease Prolactin cell Adrenocorticotropic Hormone Internal medicine Acromegaly medicine Humans Insulin Child Prolactinoma Aged business.industry Biochemistry (medical) General Medicine Middle Aged medicine.disease Prolactin Endocrinology Hypothalamus Growth Hormone Female Corticotropic cell business Hypothalamic Diseases |
| Zdroj: | Clinica Chimica Acta. 190:269-275 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/0009-8981(90)90180-z |
| Popis: | We recently demonstrated that metoclopramide acts in the hypothalamus and pituitary to release ACTH through an antidopaminergic (catecholaminergic) mechanism, and that the metoclopramide-induced cortisol response was absent in patients with prolactinoma and acromegaly with hyperprolactinemia, possibly due to an endogenous catecholamine deficiency in these diseases [l]. In the present study, to extend these observations, a 20-mg metoclopramide test was carried out on 25 patients with pituitary and/or hypothalamic disorders other than prolactinoma and acromegaly, and the results were compared with those of the insulin hypoglycemia test. |
| Databáze: | OpenAIRE |
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