Physical control of tissue morphogenesis across scales
| Autor: | Otger Campàs, Georgina A. Stooke-Vaughan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Embryogenesis Morphogenesis Embryonic Development Physical control Biology Models Biological Epithelium Article Cell biology Physical Phenomena 03 medical and health sciences 030104 developmental biology 3d space Embryonic Structure Physical phenomena Genetics Animals Animal species Process (anatomy) Developmental Biology |
| Zdroj: | Current opinion in geneticsdevelopment. 51 |
| ISSN: | 1879-0380 |
| Popis: | During embryogenesis, tissues and organs are progressively shaped into their functional morphologies. While the information about tissue and organ shape is encoded genetically, the sculpting of embryonic structures in the 3D space is ultimately a physical process. The control of physical quantities involved in tissue morphogenesis originates at cellular and subcellular scales, but it is their emergent behavior at supracellular scales that guides morphogenetic events. In this review, we highlight the physical quantities that can be spatiotemporally tuned at supracellular scales to sculpt tissues and organs during embryonic development of animal species, and connect them to the cellular and molecular mechanisms controlling them. |
| Databáze: | OpenAIRE |
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