Lithium administration and phosphate excretion
| Autor: | N. A. Kurtzman, Donald R. Rademacher, L. Nascimento, J. A. Wolfson, Jose A.L. Arruda, J. M. Richardson |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
medicine.medical_specialty
Kidney Cortex Lithium (medication) Renal cortex Thyroid Gland Parathyroid hormone Lithium Kidney Phosphates Natriuresis Parathyroid Glands Excretion chemistry.chemical_compound Dogs Physiology (medical) Internal medicine Cyclic AMP medicine Animals Cyclic adenosine monophosphate Phosphate Acetazolamide Bicarbonates medicine.anatomical_structure Endocrinology chemistry Parathyroid Hormone Adenylyl Cyclase Inhibitors Female medicine.drug |
| Zdroj: | American Journal of Physiology-Legacy Content. 231:1140-1146 |
| ISSN: | 0002-9513 |
| DOI: | 10.1152/ajplegacy.1976.231.4.1140 |
| Popis: | The phosphaturic effect of parathyroid hormone (PTH), cyclic adenosine monophosphate (cAMP), acetazolamide (Az), and HCO3 loading was studied in normal, thyroparathyroidectomized (TPTX), and Li-treated dogs. PTH administration to normal animals markedly increased fractional excretion (F) of PO4 but had a blunted effect on FPO4 in the Li-treated animals. Cyclic AMP likewise markedly increased FPO4 in the normal animals but had a markedly blunted effect in the Li-treated animals. Az led to a significant increase in FNa, FHCO3, and FPO4 in the normal animals. In the Li-treated dogs, Az induced a significant natriuresis and bicarbonaturia but failed to increase phosphaturia. HCO3 loading in normal dogs caused a significant phosphaturia while having little effect on FPO4 in Li-treated dogs. HCO3 loading to TPTX dogs was associated with a lower FPO4 as compared to normal HCO3-loaded animals. These data suggest that Li administration not only blocks the adenyl cyclase-cAMP system in the renal cortex, but it may also interfere with a step distal to the formation of cAMP, since the phosphaturic effect of both PTH and cAMP was markedly diminished in Li-treated animals. |
| Databáze: | OpenAIRE |
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