Divergent mesolimbic dopamine circuits support alcohol-seeking triggered by discrete cues and contexts
| Autor: | C. Andrew Chapman, Soraya Lahlou, Milan D. Valyear, Ivan Trujillo-Pisanty, Nadia Chaudhri, Iulia Glovaci, Audrey Zaari |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0303 health sciences
Dissociation (neuropsychology) Mesolimbic dopamine Nucleus accumbens Biology Ventral tegmental area 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Dopamine medicine Alcohol seeking Neuroscience Sensory cue 030217 neurology & neurosurgery 030304 developmental biology medicine.drug |
| DOI: | 10.1101/475343 |
| Popis: | Discrete and contextual cues that predict alcohol trigger alcohol-seeking. However, the extent to which context influences alcohol-seeking triggered by discrete cues, and the neural mechanisms underlying these responses, are not well known. We show that, relative to a neutral context, a context associated with alcohol persistently elevated alcohol-seeking triggered by a discrete cue, and supported higher levels of priming-induced reinstatement. Alcohol-seeking triggered by a discrete cue in a neutral context was reduced by designer receptor-mediated inhibition of ventral tegmental area (VTA) dopamine neurons in TH::Cre rats. Inhibiting terminals of VTA dopamine neurons in the nucleus accumbens (NAc) core reduced alcohol-seeking triggered by a discrete cue, irrespective of context, whereas inhibiting VTA dopamine terminals in the NAc shell selectively reduced the elevation of alcohol-seeking triggered by a discrete cue in an alcohol context. This dissociation highlights unique roles for divergent mesolimbic dopamine circuits in alcohol-seeking driven by discrete and contextual environmental cues. |
| Databáze: | OpenAIRE |
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