Roles of Sialic Acid, AXL, and MER Receptor Tyrosine Kinases in Mumps Virus Infection of Mouse Sertoli and Leydig Cells
| Autor: | Yongmei Chen, Xiaoqin Yu, Aijie Liu, Maolei Gong, Ruiqin Han, Qian Jiang, Fei Wang, Han Wu, Wenjing Zhang, Weihua Liu, Daishu Han, Ran Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
endocrine system Epidemic parotitis lcsh:QR1-502 Mumps virus testis medicine.disease_cause Microbiology lcsh:Microbiology Receptor tyrosine kinase Male infertility 03 medical and health sciences chemistry.chemical_compound medicine Type 1 interferon 030304 developmental biology Original Research 0303 health sciences biology 030306 microbiology urogenital system AXL medicine.disease Virology Sialic acid chemistry sialic acid MER biology.protein Orchitis mumps virus |
| Zdroj: | Frontiers in Microbiology Frontiers in Microbiology, Vol 11 (2020) |
| ISSN: | 1664-302X |
| Popis: | The mumps virus (MuV) causes epidemic parotitis. MuV also frequently infects the testis and induces orchitis, an important etiological factor contributing to male infertility. However, mechanisms underlying MuV infection of the testis remain unknown. Here, we describe that sialic acid, AXL, and MER receptor tyrosine kinases regulate MuV entry and replication in mouse major testicular cells, including Sertoli and Leydig cells. Sialic acid, AXL, and MER were present in Sertoli and Leydig cells. Sialic acid specifically mediated MuV entry into Sertoli and Leydig cells, whereas both AXL and MER facilitated MuV replication within cells through the inhibition of cellular innate antiviral responses. Mechanistically, the inhibition of type 1 interferon signaling by AXL and MER is essential for MuV replication in Sertoli and Leydig cells. Our findings provide novel insights into the mechanisms behind MuV infection and replication in the testis. |
| Databáze: | OpenAIRE |
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