Randomised study of the immunomodulatory effects of azithromycin in severely asthmatic horses
| Autor: | Jean-Pierre Lavoie, Sophie Mainguy-Seers, Amandine Vargas, Christian Bédard, Pierre Hélie, Olivia Labrecque |
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| Rok vydání: | 2018 |
| Předmět: |
Male
040301 veterinary sciences Azithromycin Proinflammatory cytokine 0403 veterinary science medicine Animals Immunologic Factors Horses Lung Asthma Inflammation Cross-Over Studies General Veterinary medicine.diagnostic_test business.industry Respiratory disease 0402 animal and dairy science 04 agricultural and veterinary sciences General Medicine respiratory system Airway obstruction medicine.disease 040201 dairy & animal science Neutrophilia respiratory tract diseases 3. Good health Respiratory Function Tests Trachea Mucus Bronchoalveolar lavage Immunology Airway Remodeling Female Horse Diseases medicine.symptom business Ceftiofur medicine.drug |
| Zdroj: | The Veterinary record. 185(5) |
| ISSN: | 2042-7670 |
| Popis: | Neutrophilic inflammation is believed to contribute to the airway obstruction and remodelling in equine asthma. Azithromycin, an antibiotic with immunomodulatory properties, reduces pulmonary neutrophilia and hyper-responsiveness in human asthmatics and decreases airway remodelling in rodent models of asthma. It was therefore hypothesised that azithromycin would improve lung function, mucus accumulation and central airway remodelling by decreasing luminal neutrophilia in severe equine asthma. The effects of a 10-day treatment with either azithromycin or ceftiofur, an antimicrobial without immune-modulating activity, were assessed using a blind, randomised, crossover design with six severe asthmatic horses in clinical exacerbation. Lung function, tracheal mucus accumulation, tracheal wash bacteriology, bronchial remodelling, airway neutrophilia and mRNA expression of proinflammatory cytokines (interleukin (IL)-8, IL-17A, IL-1β, tumour necrosis factor-α) in bronchoalveolar lavage fluid were evaluated. Azithromycin decreased the expression of IL-8 (P=0.03, one-tailed) and IL-1β (P=0.047, one-tailed) but failed to improve the other variables evaluated. Ceftiofur had no effect on any parameter. The reduction of neutrophilic chemoattractants (IL-8, IL-1β) justifies further efforts to investigate the effects of a prolonged treatment with macrolides on airway neutrophilia and remodelling. The lack of efficacy of ceftiofur suggests that severe equine asthma should not be treated with antibiotics at first-line therapy. |
| Databáze: | OpenAIRE |
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