Lead diversification. Application to existing drug molecules: mifepristone 1 and antalarmin 8

Autor:	Manuel Perez, Mark E. Bunnage, Elizabeth Farrant, Sally-Ann Fancy, Inaki Morao, Torren M. Peakman, Marc Bazin, M. Abid Masood
Rok vydání:	2011
Předmět:	Drug Metalloporphyrins media_common.quotation_subject Chemistry Pharmaceutical Clinical Biochemistry Pharmaceutical Science Biochemistry Inhibitory Concentration 50 Structure-Activity Relationship Biomimetics Drug Discovery medicine Structure–activity relationship Organic chemistry Molecule Inhibitory concentration 50 Humans Antalarmin Pyrroles Molecular Biology media_common Chemistry Organic Chemistry Mifepristone Combinatorial chemistry Carbon Oxygen Pyrimidines Models Chemical Metals Drug Design Microsomes Liver Molecular Medicine Chlorine medicine.drug Hydrogen
Zdroj:	Bioorganicmedicinal chemistry letters. 22(1)
ISSN:	1464-3405
Popis:	A series of C-H functionalisation plate-based chemical screens and other C-H activation protocols were developed for the chemical diversification of drug molecules. In this Letter, metalloporphyrin and other catalytic oxidation systems are described in addition to chlorination. Mifepristone and antalarmin are used as substrates. The products obtained and the biological data demonstrate the potential utility of this approach.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a501b2392e4f65fde8407abf88e4a3b https://pubmed.ncbi.nlm.nih.gov/22104142 Zobrazit plný text záznamu Full Text from ScienceDirect