In silico investigation of the mechanism of action of kojic acid effects via protein-protein interaction network
| Autor: | Hafsa Anam, Ghulam Murtaza, Awais Wahab, Chuan-Hong Wu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Chemistry
In silico NOS1 Pharmaceutical Science Computational biology Network pharmacology STITCH database Gene ontology Circadian regulation Transcription chemistry.chemical_compound Mechanism of action Transcription (biology) Interaction network RNA polymerase Gene expression medicine Pharmacology (medical) medicine.symptom Kojic acid |
| Zdroj: | Tropical Journal of Pharmaceutical Research; Vol. 20 No. 10 (2021); 2063-2069 |
| ISSN: | 1596-5996 1596-9827 |
| Popis: | Purpose: To evaluate the molecular mechanism of kojic acid by network pharmacology.Methods: This study was conducted by designing a protein-protein interaction network through the STITCH database and analyzing biological processes via Cytoscape plugin ClueGO.Results: A total of 19 protein targets of kojic acid including TYR, NOS3, NOS2, and NOS1 were found. The PPI network helped to understand the mode of action of kojic acid at a molecular level. Gene Ontology (GO) analysis resulted in the retrieval of 104 GO terms which were related to variousphysiological processes. GO analysis revealed that kojic acid might be involved in the regulation of several biological processes such as circadian gene expression and transcription initiation of RNA polymerase 2.Conclusion: The findings from this study reveal that the retrieved GO pathways are known to be involved in several diseases such as inflammation, cancer, aging, pigmentation, and melisma. Furthermore, these pathways are directly or indirectly related to kojic acid. Thus, this study has contributed to a better understanding of the mode of action of kojic acid. |
| Databáze: | OpenAIRE |
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