Genetic susceptibility and transmission factors in scrapie: detailed analysis of an epidemic in a closed flock of Romanov

Autor: J. P. Poivey, François Schelcher, Frédéric Lantier, Y. Amigues, Jean-Louis Laplanche, Vincent Ducrocq, Jean-Michel Elsen, F. Eychenne, J. V. Tien Khang, Olivier Andreoletti
Přispěvatelé: Station d'Amélioration Génétique des Animaux (SAGA), Institut National de la Recherche Agronomique (INRA), Station de Génétique Quantitative et Appliquée (SGQA), Unité de Pathologie Infectieuse et Immunologie [Nouzilly] (PII)
Jazyk: angličtina
Rok vydání: 1999
Předmět:
Zdroj: Archives of Virology
Archives of Virology, Springer Verlag, 1999, pp.431-445
HAL
ISSN: 0304-8608
1432-8798
Popis: Information from a scrapie epidemic in a closed INRA Romanov flock is presented. Performances, pedigree, histopathological diagnoses and PrP genotypes were recorded from the beginning of the outbreak (in 1993). Between 1st of April, 1993 and 1st of May, 1997, 1015 animals were exposed to scrapie, and 304 died from this disease. A major influence of the polymorphisms at codons 136, 154 and 171 is shown, A136H154Q171 allele carriers proving to be nearly as resistant as A136R154R171 carriers. A possible relationship between gastrointestinal parasitism and scrapie is discussed. There is evidence of maternal transmission, with a risk ratio for artificially fed lambs of 67 percent of the risk of lambs fed by their mother. Our results strongly suggest that resistant animals were not healthy carriers or at least were less infectious when comparing risk for lambs born to healthy dams either of resistant (risk = 0.431) or of susceptible (risk = 1.000) genotype.
Databáze: OpenAIRE
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