308-nm Excimer Lamp vs. Combination of 308-nm Excimer Lamp and 10% Liquor Carbonis Detergens in Patients With Scalp Psoriasis: A Randomized, Single-Blinded, Controlled Trial
| Autor: | Poonkiat Suchonwanit, Ploysyne Rattanakaemakorn, Wimolsiri Iamsumang, Korn Triyangkulsri |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Medicine (General) genetic structures Combination therapy coal tar excimer lamp targeted phototherapy Excimer law.invention 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine R5-920 Randomized controlled trial Refractory law Psoriasis medicine Original Research business.industry General Medicine medicine.disease Dermatology Excimer lamp medicine.anatomical_structure 030220 oncology & carcinogenesis Scalp Medicine business UVB Scalp psoriasis phototherapy |
| Zdroj: | Frontiers in Medicine, Vol 8 (2021) Frontiers in Medicine |
| Popis: | Background: Scalp psoriasis is usually refractory to treatment. Excimer devices have been proved to be a promising therapeutic option in psoriasis. Greater efficacy of phototherapy can be achieved by concurrent use of coal tar derivatives.Objective: We aimed to compare efficacy and safety between 308-nm excimer lamp monotherapy and a combination of 308-nm excimer lamp and 10% liquor carbonis detergens in the treatment of scalp psoriasis.Methods: In this randomized, evaluator-blinded, prospective, comparative study, 30 patients with scalp psoriasis received either 308-nm excimer lamp monotherapy or a combination of 308-nm excimer lamp and 10% liquor carbonis detergens twice per week until complete remission of the scalp or for a total of 30 sessions. Efficacy was evaluated by the improvement of Psoriasis Scalp Severity Index (PSSI) score, itch score, and Scalpdex score.Results: Both treatments induced significant improvement in PSSI score with greater reduction observed in the combination group. At 30th visit, a 75% reduction in PSSI (PSSI75) was attained by 4 (28.6%) and 9 (69.2%) patients treated with monotherapy and combination therapy, respectively (P < 0.05).Conclusions: Excimer lamp is well-tolerated in patients with scalp psoriasis and liquor carbonis detergens can be used as a combination therapy to improve the efficacy of excimer lamp. |
| Databáze: | OpenAIRE |
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