Hematological and Biochemical Factors Predicting SARS Fatality in Taiwan
| Autor: | Hsiao Ling Chang, Shu Kuan Lai, Fung-Chang Sung, Ih-Jen Su, Kow-Tong Chen, Hung Wei Kuo, Ruey S. Lin |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Adult
Male medicine.medical_specialty Neutrophils Lymphocyte Taiwan severe acute respiratory syndrome Gastroenterology Article C-reactive protein Leukocyte Count fatality Internal medicine Case fatality rate medicine Humans Respiratory system lactic acid dehydrogenase Medicine(all) lcsh:R5-920 L-Lactate Dehydrogenase biology business.industry General Medicine Odds ratio Middle Aged dyspnea lymphopenia Logistic Models medicine.anatomical_structure Immunology biology.protein Absolute neutrophil count Arterial blood Female Lactic acid dehydrogenase business lcsh:Medicine (General) |
| Zdroj: | Journal of the Formosan Medical Association, Vol 105, Iss 6, Pp 439-450 (2006) Journal of the Formosan Medical Association |
| ISSN: | 0929-6646 |
| DOI: | 10.1016/S0929-6646(09)60183-2 |
| Popis: | Background/Purpose Severe acute respiratory syndrome (SARS) has a high fatality rate worldwide. We examined the epidemiologic and clinical factors associated with death for all laboratory-confirmed SARS patients in Taiwan. Methods Using initial data in medical records reported by hospitals to the Center for Disease Control in Taiwan, we analyzed whether hematological, biochemical and arterial blood gas measures could predict fatality in 346 SARS patients. Results Both fatalities (n = 73; 21.1%) and survivors had elevated plasma concentration of initial C-reactive protein (CRP), but the mean CRP concentration was higher in fatalities (47.7 ± 43.3 mg/L) than in survivors (24.6 ± 28.2 mg/L). Initial lymphocyte counts were low in both fatalities (814 ± 378/μL) and survivors (1019 ± 480/μL). After controlling for age and sex, multiple logistic regression analysis showed that hematological factors significantly associated with fatality included initial neutrophil count > 7000/μL (odds ratio [OR] = 6.4), initial CRP concentration > 47.5 mg/L (OR = 5.8) and lactic acid dehydrogenase (LDH) > 593.5 IU/L (OR = 4.2). Factors significantly associated with initial CRP concentration > 47.5 mg/L included dyspnea (OR = 4.3), red blood cell count < 4.1 × 106/μL (OR = 4.3) and serum aspartate amino-transferase > 57 IU/L (OR = 3.1). Conclusion Initial neutrophil count, CRP and LDH levels are important predictors of mortality from SARS. [J Formos Med Assoc 2006;105(6):439-450] |
| Databáze: | OpenAIRE |
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