Genotoxicity of mixture of imidacloprid, imazalil and tebuconazole
| Autor: | O. V. Egorova, Nataliya A. Ilyushina, Valerii N. Rakitskii, Gleb V. Masaltsev, Polychronis Stivaktakis, N. S. Averianova, Aristidis Tsatsakis, Marina Goumenou, Alexander I. Vardavas, Yulia A. Revazova |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Health
Toxicology and Mutagenesis Imidacloprid 010501 environmental sciences TGAIs technical grade active ingredients Toxicology medicine.disease_cause CI confidence interval of the mean 01 natural sciences Imazalil Ames test 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Tebuconazole In vivo lcsh:RA1190-1270 medicine Food science Pesticide mixture 0105 earth and related environmental sciences ComputingMethodologies_COMPUTERGRAPHICS lcsh:Toxicology. Poisons PCE polychromatic erythrocyte RLRS Real Life Risk Simulation Regular Article Pesticide MN micronucleated NCE normochromatic erythrocyte chemistry Seed treatment Micronucleus test Genotoxicity RLRS 030217 neurology & neurosurgery |
| Zdroj: | Toxicology Reports, Vol 7, Iss, Pp 1090-1094 (2020) Toxicology Reports |
| ISSN: | 2214-7500 |
| Popis: | Graphical abstract Highlights • Imidacloprid, imazalil, tebuconazole were non-genotoxic separately. • The mixture of imidacloprid + imazalil + tebuconazole was negative in Ames test. • The mixture induced a statistically significant increase in MN-PCEs in bone marrow. • The effect observed in vivo is probably mediated by synergism of TGAIs. Genotoxicity of the mixture of generic pesticides imidacloprid + imazalil + tebuconazole in a ratio of 14.0/1.7/1.0 by weight was assessed using Ames test (Salmonella typhimurium) and micronucleus test in vivo on mammalian bone marrow erythrocytes (CD-1 mice) supporting the data creation for the Real Life Risk Simulation (RLRS) approach. This pesticides’ combination is used in the commercial formulation for seed treatment in advance of or immediately before sowing. Tested pesticides’ technical grade active ingredients (TGAIs) showed no evidence of genotoxicity upon separate treatments. In combination, the three pesticides demonstrated negative results in the Ames test but induced a statistically significant, dose-depended increase in MN-PCEs in mice bone marrow at doses lower than those used separately. The observed effect may be mediated by the synergistic action of the tested TGAIs, their metabolites or impurities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|