New insights on neurobiological mechanisms underlying alcohol addiction
| Autor: | Thomas L. Kash, Veronica A. Alvarez, Changhai Cui, Hitoshi Morikawa, Karen K. Szumlinski, Antonio Noronha, Garret D. Stuber, Mark V. Wilcox, Marisa Roberto |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pharmacology
Neuronal Plasticity Alcohol addiction Addiction media_common.quotation_subject Alcohol dependence Binge drinking Brain Article Review article Binge Drinking Behavior Addictive Cellular and Molecular Neuroscience Alcoholism Metaplasticity Neuroplasticity Structural plasticity Animals Humans Nerve Net Psychology Neuroscience Stress Psychological media_common |
| Zdroj: | Neuropharmacology. 67 |
| ISSN: | 1873-7064 |
| Popis: | Alcohol dependence/addiction is mediated by complex neural mechanisms that involve multiple brain circuits and neuroadaptive changes in a variety of neurotransmitter and neuropeptide systems. Although recent studies have provided substantial information on the neurobiological mechanisms that drive alcohol drinking behavior, significant challenges remain in understanding how alcohol-induced neuroadaptations occur and how different neurocircuits and pathways cross-talk. This review article highlights recent progress in understanding neural mechanisms of alcohol addiction from the perspectives of the development and maintenance of alcohol dependence. It provides insights on cross talks of different mechanisms and reviews the latest studies on metaplasticity, structural plasticity, interface of reward and stress pathways, and cross-talk of different neural signaling systems involved in binge-like drinking and alcohol dependence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect