Intensity of daily physical activity is associated with central hemodynamic and leg muscle oxygen availability in COPD
| Autor: | Ioannis Vogiatzis, Stavroula Spetsioti, Ioannis Nasis, Maroula Vasilopoulou, Andreas Asimakos, Zafeiris Louvaris, Eleni Kortianou, Spyros Zakynthinos |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Cardiac output Physiology Hemodynamics Walking Motor Activity Quadriceps Muscle Pulmonary Disease Chronic Obstructive Oxygen Consumption Physical medicine and rehabilitation Physiology (medical) Internal medicine Humans Medicine Muscle Strength Treadmill Dynamic hyperinflation Aged Leg COPD medicine.diagnostic_test business.industry Oxygen transport Oxygenation Middle Aged medicine.disease Oxygen Impedance cardiography Exercise Test Cardiology Female business |
| Zdroj: | Journal of Applied Physiology. 115:794-802 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00379.2013 |
| Popis: | In chronic obstructive pulmonary disease (COPD), daily physical activity is reported to be adversely associated with the magnitude of exercise-induced dynamic hyperinflation and peripheral muscle weakness. There is limited evidence whether central hemodynamic, oxygen transport, and peripheral muscle oxygenation capacities also contribute to reduced daily physical activity. Nineteen patients with COPD (FEV1, 48 ± 14% predicted) underwent a treadmill walking test at a speed corresponding to the individual patient's mean walking intensity, captured by a triaxial accelerometer during a preceding 7-day period. During the indoor treadmill test, the individual patient mean walking intensity (range, 1.5 to 2.3 m/s2) was significantly correlated with changes from baseline in cardiac output recorded by impedance cardiography (range, 1.2 to 4.2 L/min; r = 0.73), systemic vascular conductance (range, 7.9 to 33.7 ml·min−1·mmHg−1; r = 0.77), systemic oxygen delivery estimated from cardiac output and arterial pulse-oxymetry saturation (range, 0.15 to 0.99 L/min; r = 0.70), arterio-venous oxygen content difference calculated from oxygen uptake and cardiac output (range, 3.7 to 11.8 mlO2/100 ml; r = −0.73), and quadriceps muscle fractional oxygen saturation assessed by near-infrared spectrometry (range, −6 to 23%; r = 0.77). In addition, mean walking intensity significantly correlated with the quadriceps muscle force adjusted for body weight (range, 0.28 to 0.60; r = 0.74) and the ratio of minute ventilation over maximal voluntary ventilation (range, 38 to 89%, r = −0.58). In COPD, in addition to ventilatory limitations and peripheral muscle weakness, intensity of daily physical activity is associated with both central hemodynamic and peripheral muscle oxygenation capacities regulating the adequacy of matching peripheral muscle oxygen availability by systemic oxygen transport. |
| Databáze: | OpenAIRE |
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