Prognostic Molecular and Biological Characteristics of Phyllodes Tumors of the Breast
| Autor: | I.V. Vysotskaya, E.A. Kim, V.P. Letyagin, V S Buseva, V. Yu. Kirsanov, D A Denchik, I. K. Vorotnikov, M. M. Davydov |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine Somatic cell medicine.medical_treatment Mammary gland Gene Expression Loss of Heterozygosity Breast Neoplasms Minisatellite Repeats Benign Phyllodes Tumor General Biochemistry Genetics and Molecular Biology Loss of heterozygosity 03 medical and health sciences 0302 clinical medicine Breast cancer Phyllodes Tumor Biomarkers Tumor Tumor Cells Cultured Humans Medicine Receptor business.industry Cell Cycle General Medicine Middle Aged Prognosis medicine.disease Survival Analysis Steroid hormone 030104 developmental biology medicine.anatomical_structure Disease Progression Cancer research Female Breast disease Neoplasm Recurrence Local Tumor Suppressor Protein p53 business 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 169:806-810 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-020-04985-5 |
| Popis: | Prognosis for some histological variants of a rare breast disease, phyllodes tumors, is evaluated. The prognostic potential of some molecular biological factors significantly correlating with breast cancer prognosis is evaluated on a unique clinical material (244 cases with benign, intermediate, and malignant phyllodes tumors). The development of benign phyllodes tumor relapse directly correlated with the number of G0/1-phase cells and inversely correlated with the number of cells in the G2+M and S phases. The level of steroid hormone receptors in phyllodes tumors cannot serve as a prognostic marker predicting the disease course. The presence of somatic mutations of TP53 gene and loss of heterozygosity of specific intragenic loci in the tumor correlate with the development of disease relapse (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink