Influence of food commodities on hangover based on alcohol dehydrogenase and aldehyde dehydrogenase activities
| Autor: | Kriti Kumari Dubey, Rekha S. Singhal, Shraddha Srinivasan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Antioxidant
food.ingredient medicine.medical_treatment Fruit juice blends Aldehyde dehydrogenase lcsh:TX341-641 Applied Microbiology and Biotechnology Article Aldehyde dehydrogenase (ALDH) chemistry.chemical_compound food Yolk medicine Food science Ethanol metabolism Alcohol dehydrogenase chemistry.chemical_classification lcsh:TP368-456 biology Acetaldehyde food and beverages Ascorbic acid Anti-hangover formulation lcsh:Food processing and manufacture Kinetics Enzyme chemistry biology.protein Alcohol dehydrogenase (ADH) lcsh:Nutrition. Foods and food supply Food Science Biotechnology |
| Zdroj: | Current Research in Food Science Current Research in Food Science, Vol 1, Iss, Pp 8-16 (2019) |
| ISSN: | 2665-9271 |
| Popis: | Alcohol consumption often leads to hangover, a condition characterized by several symptoms, characteristically headache, nausea, fatigue and drowsiness. Hangover may be alleviated by altering the rate of alcohol metabolism and facilitating elimination of acetaldehyde by affecting the activity of alcohol dehydrogenase (ADH) and/or aldehyde dehydrogenase (ALDH) enzymes. In the present study, several food commodities like fruits, vegetables, cereals, pulses, dairy products, spices and other miscellaneous products (ascorbic acid, cocoa sample, tea, coffee, egg yolk and date samples) were investigated for their effect on the in vitro activities of the enzymes and their antioxidant properties. Of the many screened food commodities, few showed an increase in the activity of either one or both the enzymes, ADH and ALDH. Studies showed no correlation between ADH and ALDH enzyme activities and antioxidant property of the selected food commodities for anti-hangover effect. Further, an anti-hangover (AHO) product was developed using pear (65%), sweet lime (25%) and coconut water (10%) and, validated for in vitro ADH and ALDH enzyme activities. AHO product was found to enhance ADH and ALDH activities by 23.31% and 70.02%, respectively. Graphical abstract Image 1 Highlights • Screening of food influencing alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activities. • Foods commodities enhancing ADH and/or ALDH activities can be used in AHO formulation. • Pear (65%), sweetlime (25%) and coconut water(10%) used in anti-hangover (AHO) formulation. • AHO product had increased ADH (23.3%) and ALDH (70.02%) activities. |
| Databáze: | OpenAIRE |
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