Streptococcus Mutans Adhesin Biotypes that Match and Predict Individual Caries Development
| Autor: | Nongfei Sheng, Lena Mårell, Thomas Borén, Rolf Claesson, Anders Esberg, Karina Persson, Nicklas Strömberg |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Saliva 030106 microbiology Virulence lcsh:Medicine Biology Odontologi Chronic infections General Biochemistry Genetics and Molecular Biology Microbiology Streptococcus mutans 03 medical and health sciences Acid tolerance Whole saliva Chronic infectious disease lcsh:R5-920 lcsh:R General Medicine biology.organism_classification SpaP Phenotype Bacterial adhesin stomatognathic diseases 030104 developmental biology Dentistry Immunology Dental caries Adhesion lcsh:Medicine (General) |
| Zdroj: | EBioMedicine, Vol 24, Iss C, Pp 205-215 (2017) |
| ISSN: | 2352-3964 |
| Popis: | Dental caries, which affects billions of people, is a chronic infectious disease that involves Streptococcus mutans, which is nevertheless a poor predictor of individual caries development. We therefore investigated if adhesin types of S.mutans with sucrose-independent adhesion to host DMBT1 (i.e. SpaP A, B or C) and collagen (i.e. Cnm, Cbm) match and predict individual differences in caries development. The adhesin types were measured in whole saliva by qPCR in 452 12-year-old Swedish children and related to caries at baseline and prospectively at a 5-year follow-up. Strains isolated from the children were explored for genetic and phenotypic properties. The presence of SpaP B and Cnm subtypes coincided with increased 5-year caries increment, and their binding to DMBT1 and saliva correlated with individual caries scores. The SpaP B subtypes are enriched in amino acid substitutions that coincided with caries and binding and specify biotypes of S. mutans with increased acid tolerance. The findings reveal adhesin subtypes of S. mutans that match and predict individual differences in caries development and provide a rationale for individualized oral care. |
| Databáze: | OpenAIRE |
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