Thymic myoid cells express high levels of muscle genes

Autor: Sonia Berrih-Aknin, A Wakkach, Laurence Mesnard-Rouiller, Jacky Bismuth, Sandrine Poëa-Guyon
Přispěvatelé: Remodelage tissulaire et fonctionnel : signalisation et physiopathologie (RTFSP), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)
Jazyk: angličtina
Rok vydání: 2004
Předmět:
medicine.medical_specialty
MESH: Gene Expression
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Immunology
Gene Expression
Muscle Proteins
Thymus Gland
Biology
Immune tolerance
03 medical and health sciences
MESH: Muscle Proteins
0302 clinical medicine
Internal medicine
MESH: Reverse Transcriptase Polymerase Chain Reaction
Utrophin
medicine
Humans
Immunology and Allergy
ERBB3
RNA
Messenger
Gene
Cells
Cultured
030304 developmental biology
Acetylcholine receptor
MESH: RNA
Messenger
0303 health sciences
MESH: Humans
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
Reverse Transcriptase Polymerase Chain Reaction
RNA
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
Epithelial Cells
MESH: Immunohistochemistry
MESH: Thymus Gland
medicine.disease
Immunohistochemistry
Myasthenia gravis
Cell biology
Tolerance induction
Endocrinology
Neurology
MESH: Epithelial Cells
Neurology (clinical)
Stromal Cells
MESH: Stromal Cells
030217 neurology & neurosurgery
MESH: Cells
Cultured
Zdroj: Journal of Neuroimmunology
Journal of Neuroimmunology, Elsevier, 2004, 148 (1-2), pp.97-105. ⟨10.1016/j.jneuroim.2003.11.013⟩
ISSN: 0165-5728
DOI: 10.1016/j.jneuroim.2003.11.013⟩
Popis: International audience; To explore the possible contribution of thymic myoid cells in tolerance induction mechanisms, we quantified by real-time RT-PCR, the expression of 12 muscle genes (the five subunits of acetylcholine receptor, Musk, rapsyn, utrophin, ErbB2, ErbB3, troponin T, and MCK) in a human thymic myoid cell line (MITC), compared to thymic epithelial cells (TEC) and thymocytes. Although expression of all the genes analyzed was detected in TEC and thymocytes, the level of expression in these cells was much lower than in MITC, except for -AChR, utrophin and ErbB3 genes. Since myoid cells express high level of most muscle genes and are consistently found in the thymic medulla, they may contribute to the mechanisms involved in the induction and maintenance of immune tolerance.
Databáze: OpenAIRE
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