Does mild intrahepatic cholestasis of pregnancy require an aggressive management? Evidence from a prospective observational study focused on adverse perinatal outcomes and pathological placental findings
| Autor: | Maria Immacolata Ferraro, Cinzia Carrozza, Giulia Maria Sassara, Marta Tomaselli, Stefania Triunfo, Elisabetta Latartara |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Cholagogues and Choleretics Placental Finding Placenta Cholestasis Intrahepatic 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Humans 030212 general & internal medicine Prospective Studies Pathological Obstetrics business.industry Cesarean Section Obstetrics and Gynecology medicine.disease Pregnancy Complications medicine.anatomical_structure Pediatrics Perinatology and Child Health 030211 gastroenterology & hepatology Observational study Female business Cholestasis of pregnancy |
| Zdroj: | The journal of maternal-fetalneonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 35(2) |
| ISSN: | 1476-4954 |
| Popis: | To ascertain the most effective approach in pregnancies complicated by mild intrahepatic cholestasis of pregnancy (mICP) by evaluating rates of adverse perinatal outcomes (APOs) and pathological placental findings.A total of 89 pregnancies complicated by mICP (defined as total serum bile acids (TSBAs) levels40 µmol/L) were included. One-drug (ursodeoxycholic acid [UDCA]) (No differences were found in demographic, obstetric, and placental characteristics. In UDCAPregnancies complicated by mICP and managed by UDCA alone present similar APO rates and placental histopathology if compared with those treated by UDCA |
| Databáze: | OpenAIRE |
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